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Literature summary extracted from

  • Ohayon, R.; Boeynaems, J.M.; Braekman, J.C.; Van den Bergen, H.; Gorin, Y.; Virion, A.
    Inhibition of thyroid NADPH-oxidase by 2-iodohexadecanal in a cell-free system (1994), Mol. Cell. Endocrinol., 99, 133-141.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.3.1 2-bromohexadecanal irreversible Sus scrofa
1.6.3.1 2-iodohexadecanal irreversible Sus scrofa
1.6.3.1 2-iodoicosanal weak inhibition Sus scrofa
1.6.3.1 2-iodooctanal irreversible Sus scrofa
1.6.3.1 dodecanal reversible Sus scrofa
1.6.3.1 hexadecanal reversible Sus scrofa
1.6.3.1 additional information non-iodinated lipid aldehydes inhibit depending on their chain length, maximum inhibition with dodecanal and tridecanal, no inhibition with octanal Sus scrofa
1.6.3.1 N-ethylmaleimide
-
 Sus scrofa
1.6.3.1 p-hydroxymercuribenzoate
-
 Sus scrofa
1.6.3.1 sulfosuccinimidyl-3-(4-hydroxyphenyl) propionate
-
 Sus scrofa
1.6.3.1 tridecanal reversible Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.6.3.1 apical plasma membrane
-
 Sus scrofa 16324
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.6.3.1 Ca2+ regulates enzyme activity Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.6.3.1 NAD(P)H + H+ + O2 Sus scrofa production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis NAD(P)+ + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.6.3.1 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.3.1 thyroid gland
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.3.1 NAD(P)H + H+ + O2
-
 Sus scrofa NAD(P)+ + H2O2
-
 ?
1.6.3.1 NAD(P)H + H+ + O2 production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis Sus scrofa NAD(P)+ + H2O2
-
 ?