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Literature summary extracted from

  • Wilson, A.L.; Erdman, R.A.; Castellano, F.; Maltese, W.A.
    Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases (1998), Biochem. J., 333, 497-504.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.59
-
Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.59 GGTI-297
-
Rattus norvegicus
2.5.1.59 GGTI-298
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.60 geranylgeranyl diphosphate + protein-cysteine Bos taurus the Rab protein Rab8-GTPase, which end with a Cys-Val-Leu-Leu motif able to serve as a substrate for either geranylgeranyl transferase I and II, but modified predominantly by either geranylgeranyl transferase II in vivo S-geranylgeranyl-protein + diphosphate
-
?
2.5.1.60 geranylgeranyl diphosphate + protein-cysteine Bos taurus reaction is critical for membrane localization of Rab proteins and for their interaction with soluble regulatory proteins S-geranylgeranyl-protein + diphosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.59 Rattus norvegicus
-
-
-
2.5.1.60 Bos taurus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.59 geranylgeranyl diphosphate + protein-cysteine the Rab protein Rab8-GTPase, which ends with a Cys-Val-Leu-Leu motif is able to serve as a substrate for either geranylgeranyl transferase I and II, but modified predominantly by geranylgeranyl transferase II, Y78D mutation selective prevents prenylation of Rab8 by geranylgeranyl transferase II, but not geranylgeranyltransferaseI Rattus norvegicus S-geranylgeranyl-protein + diphosphate
-
?
2.5.1.60 geranylgeranyl diphosphate + protein-cysteine enzyme attaches geranylgeranyl groups to two C-terminal cysteines in Ras-related GTPases of a single family, the Rab family, Ypt/Sec4 in lower eukaryotes, that terminate in XXCC, XCXC and CCXX motifs, reaction only if Rab is bound to a carrier protein termed Rab escort protein, REP Bos taurus S-geranylgeranyl-protein + diphosphate
-
?
2.5.1.60 geranylgeranyl diphosphate + protein-cysteine Rab protein forms a stable complex with Rab escort protein, REP Bos taurus S-geranylgeranyl-protein + diphosphate
-
?
2.5.1.60 geranylgeranyl diphosphate + protein-cysteine the Rab protein Rab8-GTPase, which end with a Cys-Val-Leu-Leu motif able to serve as a substrate for either geranylgeranyl transferase I and II, but modified predominantly by either geranylgeranyl transferase II in vivo Bos taurus S-geranylgeranyl-protein + diphosphate
-
?
2.5.1.60 geranylgeranyl diphosphate + protein-cysteine reaction is critical for membrane localization of Rab proteins and for their interaction with soluble regulatory proteins Bos taurus S-geranylgeranyl-protein + diphosphate
-
?
2.5.1.60 geranylgeranyl diphosphate + Rab1B
-
Bos taurus ?
-
?
2.5.1.60 geranylgeranyl diphosphate + Rab8 the Rab protein Rab8-GTPase, which end with a Cys-Val-Leu-Leu motif able to serve as a substrate for either geranylgeranyl transferase I and II, but modified predominantly by either geranylgeranyl transferase II in vitro, but the mutation of Y78D prevents Rab8 from serving as a substrate Bos taurus ?
-
?