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Literature summary extracted from

  • Waterhouse, M.J.; Chia, Y.C.; Lees, G.J.
    Inhibition of human and rat hepatic aminotransferase activity with L-3,4-dihydroxyphenylalanine by inhibitors of peripheral aromatic amino acid decarboxylase (1979), Mol. Pharmacol., 15, 108-114.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.49 3-hydroxy-4-benzyloxyamine dihydrogen phosphate NSD 1055, up to 30 mM Homo sapiens
2.6.1.49 3-hydroxy-4-benzyloxyamine dihydrogen phosphate NSD 1055, up to 30 mM Rattus norvegicus
2.6.1.49 carbidopa MK 486, inhibition is more marked if 2-oxoglutarate is used as amino group acceptor rather than phenylpyruvate, pyridoxal 5'-phosphate protects Rattus norvegicus
2.6.1.49 additional information not inhibited by benserazide Homo sapiens
2.6.1.49 additional information not inhibited by benserazide Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.49 Homo sapiens
-
-
-
2.6.1.49 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.49 liver
-
 Homo sapiens
-
2.6.1.49 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.49 3-(3,4-dihydroxyphenyl)-L-alanine + 2-oxoglutarate i.e. L-dopa Homo sapiens 3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate i.e. DOPP ?
2.6.1.49 3-(3,4-dihydroxyphenyl)-L-alanine + 2-oxoglutarate i.e. L-dopa Rattus norvegicus 3-(3,4-dihydroxyphenyl)pyruvate + L-glutamate i.e. DOPP ?
2.6.1.49 3-(3,4-dihydroxyphenyl)-L-alanine + 3-phenylpyruvate i.e. L-dopa Homo sapiens 3-(3,4-dihydroxyphenyl)pyruvate + L-phenylalanine
-
 ?
2.6.1.49 3-(3,4-dihydroxyphenyl)-L-alanine + 3-phenylpyruvate i.e. L-dopa Rattus norvegicus 3-(3,4-dihydroxyphenyl)pyruvate + L-phenylalanine
-
 ?
2.6.1.49 L-tyrosine + 2-oxoglutarate 8% of activity with L-Dopa Homo sapiens 3-(4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
-
 ?
2.6.1.49 L-tyrosine + 2-oxoglutarate 8% of activity with L-Dopa Rattus norvegicus 3-(4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
-
 ?