Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Martinez-Carrion, M.; Jenkins, W.T.
    D-Alanine-D-glutamate transaminase. II. Inhibitors and the mechanism of transamination of D-amino acids (1965), J. Biol. Chem., 240, 3547-3552.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.21 aminooxyacetic acid 0.0001 mM, 50% inhibition Bacillus subtilis
2.6.1.21 cysteine inhibition of D- and L-transamination of D-alanine to 2-oxoglutarate Bacillus subtilis
2.6.1.21 D-2-aminobutanoate inhibition of D- and L-transamination of D-alanine to 2-oxoglutarate, weak Bacillus subtilis
2.6.1.21 D-asparagine inhibition of D- and L-transamination of D-alanine to alpha-ketoglutarate, weak Bacillus subtilis
2.6.1.21 D-Aspartate inhibition of D- and L-transamination of D-alanine to 2-oxoglutarate, weak Bacillus subtilis
2.6.1.21 D-cysteine 0.1 mM, 60% inhibition Bacillus subtilis
2.6.1.21 D-glutamate competitive to D-alanine, noncompetitive to 2-oxoglutarate Bacillus subtilis
2.6.1.21 D-methionine inhibition of D- and L-transamination of D-alanine to 2-oxoglutarate, weak Bacillus subtilis
2.6.1.21 D-oxamycin 0.000025 mM, 50% inhibition Bacillus subtilis
2.6.1.21 D-serine inhibition of D- and L-transamination of D-alanine to 2-oxoglutarate Bacillus subtilis
2.6.1.21 DL-alpha-Methylserine inhibition of D- and L-transamination of D-alanine to alpha-ketoglutarate, weak Bacillus subtilis
2.6.1.21 hydroxylamine 0.1 mM, 91% inhibition Bacillus subtilis
2.6.1.21 L-cysteine 2 mM, 49% inhibition Bacillus subtilis
2.6.1.21 L-oxamycin 0.001 mM, 50% inhibition Bacillus subtilis
2.6.1.21 L-serine 10 mM, 22% inhibition Bacillus subtilis
2.6.1.21 Maleate 12 mM, 30% inhibition at pH 7.1, no inhibition at pH 8.3 Bacillus subtilis
2.6.1.21 additional information not inhibited by malic acid, KCN, iodoacetic acid, p-chloromercuribenzoate and HgCl2 Bacillus subtilis
2.6.1.21 oxamycin D-isomer by a factor of 40 more inhibitory than L-isomer Bacillus subtilis
2.6.1.21 succinate 12 mM, 18% inhibition at pH 7.1, no inhibition at pH 8.3 Bacillus subtilis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.21 3.4
-
 2-oxoglutarate cosubstrate D-alanine Bacillus subtilis

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.21 Bacillus subtilis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.21 D-alanine + pyruvate
-
 Bacillus subtilis pyruvate + D-alanine
-
 ?