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Literature summary extracted from

  • Maître, M.; Ciesielski, L.; Cash, C.; Mandel, P.
    Comparison of the structural characteristics of the 4-aminobutyrate:2-oxoglutarate transaminases from rat and human brain, and of their affinities for certain inhibitors (1978), Biochim. Biophys. Acta, 522, 385-399.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.19 Branched-chain fatty acids
-
 Homo sapiens
2.6.1.19 Branched-chain fatty acids
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.19 additional information
-
 additional information
-
 Homo sapiens
2.6.1.19 additional information
-
 additional information
-
 Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.6.1.19 57000
-
 2 * 57000, SDS-PAGE Homo sapiens
2.6.1.19 57000
-
 2 * 57000, SDS-PAGE with or without DTT or urea Rattus norvegicus
2.6.1.19 105000
-
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.19 Homo sapiens
-
-
-
2.6.1.19 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.19
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.19 brain
-
 Homo sapiens
-
2.6.1.19 brain
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.6.1.19 2.5
-
 38°C, pH 8.6 Rattus norvegicus
2.6.1.19 4.9
-
-
 Homo sapiens
2.6.1.19 4.9
-
 38°C, pH 8.6 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.19 4-aminobutanoate + 2-oxoglutarate
-
 Homo sapiens 4-oxobutanoate + L-glutamate
-
 r
2.6.1.19 4-aminobutanoate + 2-oxoglutarate
-
 Rattus norvegicus 4-oxobutanoate + L-glutamate
-
 r
2.6.1.19 beta-alanine + 2-oxoglutarate
-
 Homo sapiens malonic semialdehyde + L-glutamate
-
 r
2.6.1.19 beta-alanine + 2-oxoglutarate
-
 Rattus norvegicus malonic semialdehyde + L-glutamate
-
 r

Subunits

EC Number Subunits Comment Organism
2.6.1.19 dimer 2 * 57000, SDS-PAGE Homo sapiens
2.6.1.19 dimer 2 * 57000, SDS-PAGE with or without DTT or urea Rattus norvegicus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.6.1.19 55
-
 rapid inactivation Rattus norvegicus
2.6.1.19 55
-
 slow inactivation Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.6.1.19 8.5
-
-
 Homo sapiens
2.6.1.19 8.5
-
-
 Rattus norvegicus
2.6.1.19 8.5 8.6
-
 Rattus norvegicus