Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Tamaki, N.; Kubo, K.; Aoyama, H.; Funatsuka, A.
    Inhibitory effect of 6-azauracil on purified rabbit liver 4-aminobutyrate aminotransferase (1983), J. Biochem., 93, 955-959.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.19 2-oxoglutarate
-
 Oryctolagus cuniculus
2.6.1.19 2-Thiouracil weak Oryctolagus cuniculus
2.6.1.19 5-Diazouracil weak Oryctolagus cuniculus
2.6.1.19 5-fluorouracil weak Oryctolagus cuniculus
2.6.1.19 5-Iodouracil 84% inhibition at 1 mM Oryctolagus cuniculus
2.6.1.19 5-Nitrouracil weak Oryctolagus cuniculus
2.6.1.19 5-Thiouracil weak Oryctolagus cuniculus
2.6.1.19 Aminooxyacetate 99% inhibition at 1 mM Oryctolagus cuniculus
2.6.1.19 beta-Alanine not Oryctolagus cuniculus
2.6.1.19 cycloserine 90% inhibition at 1 mM Oryctolagus cuniculus
2.6.1.19 D-cycloserine
-
 Oryctolagus cuniculus
2.6.1.19 gabaculine 98% inhibition at 1 mM Oryctolagus cuniculus
2.6.1.19 glyoxylate weak Oryctolagus cuniculus
2.6.1.19 additional information no inhibition by 6-azauridine, 6-azauridine 5'-phosphate, uracil, (iso)orotic acid, cytosine, thymine, dihydrothymine, 2-thiocytosine, thiourea; not inhibitory: 5-aminouracil Oryctolagus cuniculus
2.6.1.19 oxalacetate
-
 Oryctolagus cuniculus
2.6.1.19 pyruvate
-
 Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.19 0.13 0.27 2-oxoglutarate 37°C, pH 7.3 Oryctolagus cuniculus
2.6.1.19 18
-
 beta-Alanine
-
 Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.19 Oryctolagus cuniculus
-
-
-

Renatured (Commentary)

EC Number Renatured (Comment) Organism
2.6.1.19 enzyme inhibited by 6-azauracil is reactivated by dialysis but not by addititon of pyridoxal 5'-phosphate Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.19 liver
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.19 4-aminobutanoate + 2-oxoglutarate
-
 Oryctolagus cuniculus 4-oxobutanoate + L-glutamate
-
 r
2.6.1.19 beta-alanine + 2-oxoglutarate
-
 Oryctolagus cuniculus malonic semialdehyde + L-glutamate
-
 r