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Literature summary extracted from

  • Montfort, W.R.
    Complementing thymidylate synthase (2003), Structure, 11, 607-608.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.148 NADH required to reduce bound FAD Dictyostelium discoideum
2.1.1.148 NADH required to reduce bound FAD Thermotoga maritima
2.1.1.148 NADPH required to reduce bound FAD Dictyostelium discoideum
2.1.1.148 NADPH required to reduce bound FAD Thermotoga maritima

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.148 5,10-methylenetetrahydrofolate + dUMP + FADH2 Dictyostelium discoideum
-
 dTMP + tetrahydrofolate + FAD
-
 ?
2.1.1.148 5,10-methylenetetrahydrofolate + dUMP + FADH2 Thermotoga maritima
-
 dTMP + tetrahydrofolate + FAD
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.148 Dictyostelium discoideum
-
-
-
2.1.1.148 Thermotoga maritima Q9WYT0
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.148 5,10-methylenetetrahydrofolate + dUMP + FADH2
-
 Dictyostelium discoideum dTMP + tetrahydrofolate + FAD
-
 ?
2.1.1.148 5,10-methylenetetrahydrofolate + dUMP + FADH2
-
 Thermotoga maritima dTMP + tetrahydrofolate + FAD
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.1.148 FAD tightly bound, four molecules per tetramer Dictyostelium discoideum
2.1.1.148 FAD tightly bound, four molecules per tetramer Thermotoga maritima