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Literature summary extracted from

  • Cooper, A.J.L.
    Asparagine transaminase from rat liver (1977), J. Biol. Chem., 252, 2032-2038.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.14 glycine
-
Rattus norvegicus
2.6.1.14 homoserine asparagine/pyruvate reaction; DL-isomer Rattus norvegicus
2.6.1.14 L-2-aminobutanoate weak, asparagine/pyruvate reaction Rattus norvegicus
2.6.1.14 L-alanine weak, asparagine/pyruvate reaction Rattus norvegicus
2.6.1.14 L-aspartate
-
Rattus norvegicus
2.6.1.14 L-glutamine
-
Rattus norvegicus
2.6.1.14 L-methionine-SR-sulfoxime asparagine/pyruvate reaction Rattus norvegicus
2.6.1.14 leucine asparagine/pyruvate reaction; weak Rattus norvegicus
2.6.1.14 methionine asparagine/pyruvate reaction; L-isomer Rattus norvegicus
2.6.1.14 S-methyl-L-cysteine asparagine/pyruvate reaction Rattus norvegicus
2.6.1.14 serine asparagine/pyruvate reaction Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.14 0.077
-
glyoxylate cosubstrate L-asparagine Rattus norvegicus
2.6.1.14 0.35
-
4-methylsulfanyl-2-oxobutanoate cosubstrate L-asparagine Rattus norvegicus
2.6.1.14 0.45
-
phenylpyruvate cosubstrate L-asparagine Rattus norvegicus
2.6.1.14 2.5
-
2-oxosuccinamate cosubstrate L-asparagine Rattus norvegicus
2.6.1.14 5.1
-
pyruvate cosubstrate L-asparagine Rattus norvegicus
2.6.1.14 100
-
2-oxobutanoate cosubstrate L-asparagine Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.14 glyoxylate + amino acid Rattus norvegicus
-
?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.14 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.14
-
Rattus norvegicus

Reaction

EC Number Reaction Comment Organism Reaction ID
2.6.1.14 L-asparagine + a 2-oxo carboxylate = 2-oxosuccinamate + an amino acid ping-pong mechanism Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.14 liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.6.1.14 additional information
-
similar activity in glycylglycine, ammediol and Tris/HCl buffer Rattus norvegicus
2.6.1.14 0.25
-
-
Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.14 2-oxosuccinamic acid + aspartate
-
Rattus norvegicus L-asparagine + 2-oxo-propane-1,3-dioate
-
?
2.6.1.14 2-oxosuccinamic acid + L-2-aminobutanoic acid
-
Rattus norvegicus L-asparagine + 2-oxobutanoate
-
r
2.6.1.14 2-oxosuccinamic acid + L-alanine
-
Rattus norvegicus L-asparagine + pyruvate
-
?
2.6.1.14 2-oxosuccinamic acid + L-cysteine
-
Rattus norvegicus L-asparagine + 3-mercapto-2-oxopropanoate
-
?
2.6.1.14 2-oxosuccinamic acid + L-glutamine
-
Rattus norvegicus L-asparagine + L-glutamate
-
?
2.6.1.14 2-oxosuccinamic acid + L-homoserine
-
Rattus norvegicus L-asparagine + 4-hydroxy-2-oxobutanoate
-
?
2.6.1.14 2-oxosuccinamic acid + L-leucine
-
Rattus norvegicus L-asparagine + 4-methyl-2-oxopentanoate
-
?
2.6.1.14 2-oxosuccinamic acid + L-methionine
-
Rattus norvegicus L-asparagine + 4-methylsulfanyl-2-oxobutanoate
-
r
2.6.1.14 2-oxosuccinamic acid + L-methylcysteine
-
Rattus norvegicus L-asparagine + ?
-
?
2.6.1.14 2-oxosuccinamic acid + L-phenylalanine
-
Rattus norvegicus L-asparagine + 2-oxo-3-phenylpropanoate
-
?
2.6.1.14 2-oxosuccinamic acid + L-serine
-
Rattus norvegicus L-asparagine + 3-hydroxy-2-oxopropanoate
-
?
2.6.1.14 glyoxylate + amino acid
-
Rattus norvegicus ?
-
?
2.6.1.14 glyoxylate + L-asparagine
-
Rattus norvegicus ? + 2-oxosuccinamate
-
?
2.6.1.14 L-asparagine + 2-oxobutanoate weak Rattus norvegicus 2-oxosuccinamate + 2-aminobutanoate
-
r
2.6.1.14 L-asparagine + 2-oxosuccinamate
-
Rattus norvegicus 2-oxosuccinamate + L-asparagine
-
?
2.6.1.14 L-asparagine + 4-methylsulfanyl-2-oxobutanoate
-
Rattus norvegicus 2-oxosuccinamate + L-methionine
-
r
2.6.1.14 L-asparagine + glyoxylate
-
Rattus norvegicus 2-oxosuccinamate + glycine
-
?
2.6.1.14 L-asparagine + pyruvate
-
Rattus norvegicus 2-oxosuccinamate + L-alanine
-
?
2.6.1.14 additional information the following 2-oxo acids are inactive at concentrations of 20 mM: 2-oxoglutarate, oxaloacetate, 2-oxoisopentanoate, L-2-oxo-3-methylvalerate, 3-sulfopyruvate, 3-hydroxy-2-oxobutanoate, trimethylpyruvate Rattus norvegicus ?
-
?
2.6.1.14 phenylpyruvate + L-asparagine
-
Rattus norvegicus L-phenylalanine + 2-oxosuccinamate
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.6.1.14 37
-
assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.6.1.14 8.5 8.6
-
Rattus norvegicus