Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Martin, R.G.
    The first enzyme in histidine biosynthesis: the nature of feedback inhibition by histidine (1963), J. Biol. Chem., 238, 257-268.
No PubMed abstract available

General Stability

EC Number General Stability Organism
2.4.2.17 L-histidine, 0.4 mM, stabilizes against heat inactivation, 0.04 mM does not stabilize against heat inactivation, at 1.33 mM and higher heat inactivation is greater than the control Salmonella enterica subsp. enterica serovar Typhimurium

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.17 2-methyl-L-histidine
-
Salmonella enterica subsp. enterica serovar Typhimurium
2.4.2.17 2-thiazol-DL-alanine
-
Salmonella enterica subsp. enterica serovar Typhimurium
2.4.2.17 adenine competitive to ATP and 5-phospho-alpha-D-ribose 1-diphosphate Salmonella enterica subsp. enterica serovar Typhimurium
2.4.2.17 ADP competitive to ATP, in the presence of histidine inhibition by AMP and ADP becomes positively cooperative and much more potent Salmonella enterica subsp. enterica serovar Typhimurium
2.4.2.17 Ag+
-
Salmonella enterica subsp. enterica serovar Typhimurium
2.4.2.17 AMP competitive inhibitor to 5-phospho-alpha-D-ribose 1-diphosphate, in the presence of histidine inhibition by AMP and ADP becomes positively cooperative and much more potent Salmonella enterica subsp. enterica serovar Typhimurium
2.4.2.17 Cd2+
-
Salmonella enterica subsp. enterica serovar Typhimurium
2.4.2.17 Co2+
-
Salmonella enterica subsp. enterica serovar Typhimurium
2.4.2.17 Cu2+
-
Salmonella enterica subsp. enterica serovar Typhimurium
2.4.2.17 Hg2+
-
Salmonella enterica subsp. enterica serovar Typhimurium
2.4.2.17 L-histidine feed-back inhibition; reversed by Hg2+, p-hydroxymercuribenzoate, methylmercuric bromide, Ni2+; the L-configuration is essential, substitution of alpha-amino group appreciably reduces inhibition, non competitive inhibitor with respect to both substrates Salmonella enterica subsp. enterica serovar Typhimurium
2.4.2.17 Methylmercuric bromide
-
Salmonella enterica subsp. enterica serovar Typhimurium
2.4.2.17 N-ethylmaleimide
-
Salmonella enterica subsp. enterica serovar Typhimurium
2.4.2.17 Ni2+
-
Salmonella enterica subsp. enterica serovar Typhimurium
2.4.2.17 p-hydroxymercuribenzoate
-
Salmonella enterica subsp. enterica serovar Typhimurium
2.4.2.17 Zn2+
-
Salmonella enterica subsp. enterica serovar Typhimurium

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.17 0.067
-
5-phospho-alpha-D-ribose 1-diphosphate
-
Salmonella enterica subsp. enterica serovar Typhimurium
2.4.2.17 0.2
-
ATP
-
Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.17 ATP + 5-phospho-alpha-D-ribose 1-diphosphate Salmonella enterica subsp. enterica serovar Typhimurium first step in histidine biosynthesis diphosphate + N-1-(5'-phosphoribosyl)-ATP
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.17 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.17 ammonium sulfate precipitation and DEAE-cellulose chromatography Salmonella enterica subsp. enterica serovar Typhimurium

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.2.17 additional information
-
description of assay method Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.17 ATP + 5-phospho-alpha-D-ribose 1-diphosphate
-
Salmonella enterica subsp. enterica serovar Typhimurium 1-(5-phospho-D-ribosyl)-ATP + diphosphate
-
?
2.4.2.17 ATP + 5-phospho-alpha-D-ribose 1-diphosphate first step in histidine biosynthesis Salmonella enterica subsp. enterica serovar Typhimurium diphosphate + N-1-(5'-phosphoribosyl)-ATP
-
?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.4.2.17 45
-
very sensitive to heat inactivation, 0.4 mM histidine stabilizes the enzyme to inactivation by heat Salmonella enterica subsp. enterica serovar Typhimurium

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.17 8.5
-
assay at Salmonella enterica subsp. enterica serovar Typhimurium