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Literature summary extracted from

  • Kim, K.; Lawrence, S.M.; Park, J.; Pitts, L.; Vann, W.F.; Betenbaugh, M.J.; Palter, K.B.
    Expression of a functional Drosophila melanogaster N-acetylneuraminic acid (Neu5Ac) phosphate synthase gene: Evidence for endogenous sialic acid biosynthetic ability in insects (2002), Glycobiology, 12, 73-83.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.57
-
 Drosophila melanogaster
2.5.1.57
-
 Homo sapiens
2.5.1.57 cloned and expressed in either bacterial or baculoviral expression systems Drosophila melanogaster

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.57 41000
-
 SDS-PAGE Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.57 N-acetyl-D-mannosamine 6-phosphate + phosphoenolpyruvate + H2O Escherichia coli
-
 N-acetyl-neuraminate 9-phosphate + phosphate
-
 ?
2.5.1.57 N-acetyl-D-mannosamine 6-phosphate + phosphoenolpyruvate + H2O Drosophila melanogaster sialic acid biosynthesis N-acetyl-neuraminate 9-phosphate + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.57 Drosophila melanogaster
-
 sialic acid synthase, single genomic clone
-
2.5.1.57 Drosophila melanogaster Q9VG74 sialic acid synthase cDNA sequence
-
2.5.1.57 Escherichia coli
-
 neuB gene product amino acid sequence accession. no.
-
2.5.1.57 Homo sapiens Q9NR45 amino acid sequence
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.57 embryo
-
 Drosophila melanogaster
-
2.5.1.57 larva
-
 Drosophila melanogaster
-
2.5.1.57 SCHNEIDER-2 cell
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.57 D-mannose 6-phosphate + phosphoenolpyruvate + H2O
-
 Drosophila melanogaster 2-keto-3-deoxy-D-glycero-D-galactononoic acid 9-phosphate + phosphate
-
 ?
2.5.1.57 N-acetyl-D-mannosamine 6-phosphate + phosphoenolpyruvate + H2O
-
 Drosophila melanogaster N-acetyl-neuraminate 9-phosphate + phosphate
-
 ?
2.5.1.57 N-acetyl-D-mannosamine 6-phosphate + phosphoenolpyruvate + H2O
-
 Escherichia coli N-acetyl-neuraminate 9-phosphate + phosphate
-
 ?
2.5.1.57 N-acetyl-D-mannosamine 6-phosphate + phosphoenolpyruvate + H2O sialic acid biosynthesis Drosophila melanogaster N-acetyl-neuraminate 9-phosphate + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.57 DmSAS
-
 Drosophila melanogaster