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Literature summary extracted from

  • Teclebrhan, H.; Olsson, J.; Swiezewska, E.; Dallner, G.
    Biosynthesis of the side chain of ubiquinone:trans-prenyltransferase in rat liver microsomes (1993), J. Biol. Chem., 268, 23081-23086.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.5.1.84 Digitonin
-
 Rattus norvegicus
2.5.1.84 Digitonin 0.005%, 29fold activation Rattus norvegicus
2.5.1.84 taurodeoxycholate 0.005%, 1.3fold activation Rattus norvegicus
2.5.1.84 Tween-80 0.005%, 1.4fold activation Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.84 1-O-octyl-beta-D-glucopyranoside 0.1%, 44% inhibition Rattus norvegicus
2.5.1.84 Ca2+ 1 mM (in absence of Mn2+ or Mg2+), complete inhibition Rattus norvegicus
2.5.1.84 deoxycholate 0.01%, 70% inhibition Rattus norvegicus
2.5.1.84 SDS 0.005%, 78% inhibition Rattus norvegicus
2.5.1.84 Triton X-100 0.05%, 53% inhibition Rattus norvegicus
2.5.1.84 Zn2+ 1 mM (in absence of Mn2+ or Mg2+), complete inhibition Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.5.1.84 microsome
-
 Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.5.1.84 Mg2+ no activity in absence of divalent metal ion, activation with 2 mM Mg2+ is 50% of that obtained with Mn2+ Rattus norvegicus
2.5.1.84 Mn2+ no activity in absence of divalent metal ion, 0.1 mM Mn2+ is required for optimal activity Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.84 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.84 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.84 all-trans-farnesyl diphosphate + 6 isopentenyl diphosphate about 10% of the activity with geranyl diphosphate Rattus norvegicus 6 diphosphate + all-trans-nonaprenyl diphosphate
-
 ?
2.5.1.84 geranyl diphosphate + 7 isopentenyl diphosphate
-
 Rattus norvegicus 7 diphosphate + all-trans-nonaprenyl diphosphate
-
 ?
2.5.1.84 geranylgeranyl diphosphate + 5 isopentenyl diphosphate about 25% of the activity with geranyl diphosphate Rattus norvegicus 5 diphosphate + all-trans-nonaprenyl diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.84 ubiquinone:trans-prenyltransferase
-
 Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.5.1.84 8
-
-
 Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.5.1.84 7 9.5 pH 7.0: about 60% of maximal activity, pH 9.5: about 60% of maximal activity Rattus norvegicus