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Literature summary extracted from

  • Arnold, W.J.; Kelley, W.N.
    Adenine phosphoribosyltransferase (1978), Methods Enzymol., 51, 568-574.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.7 ADP
-
 Homo sapiens
2.4.2.7 AMP
-
 Homo sapiens
2.4.2.7 citrate
-
 Homo sapiens
2.4.2.7 GMP
-
 Homo sapiens
2.4.2.7 Hg2+
-
 Homo sapiens
2.4.2.7 iodoacetate
-
 Homo sapiens
2.4.2.7 Na+
-
 Homo sapiens
2.4.2.7 nucleotides nucleotide mono-, di- and triphosphates of adenine, guanine and hypoxanthine Homo sapiens
2.4.2.7 p-hydroxymercuribenzoate not enzyme from monkey liver Homo sapiens
2.4.2.7 SO42-
-
 Homo sapiens
2.4.2.7 succinate
-
 Homo sapiens
2.4.2.7 sulfhydryl reagents
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.7 0.006
-
 5-phospho-alpha-D-ribose 1-diphosphate
-
 Homo sapiens
2.4.2.7 0.14
-
 adenine
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.2.7 cytosol exclusively Homo sapiens 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.2.7 Ca2+
-
 Homo sapiens
2.4.2.7 Co2+
-
 Homo sapiens
2.4.2.7 Mg2+ required Homo sapiens
2.4.2.7 Mg2+ absolute requirement Homo sapiens
2.4.2.7 Mg2+ Mg2+ most effective Homo sapiens
2.4.2.7 Mg2+ maximal activity if Mg2+ is twice the concentration of 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens
2.4.2.7 Mn2+
-
 Homo sapiens
2.4.2.7 additional information descendring order of efficency: Mg2+, Mn2+, Ca2+, Co2+, Ni2+, Zn2+ Homo sapiens
2.4.2.7 additional information activity absolutely depends on presence of divalent cations Homo sapiens
2.4.2.7 Ni2+
-
 Homo sapiens
2.4.2.7 Zn2+
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.2.7 34000
-
 gel filtration, sucrose density gradient ultracentrifugation Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.7 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.7
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.7 erythrocyte
-
 Homo sapiens
-
2.4.2.7 additional information human enzyme found in all tissues with the highest specific activity in nucleated cells Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.2.7 9.58
-
 purified enzyme Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.7 2,6-diaminopurine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Homo sapiens 2,6-diaminopurine ribotide + diphosphate
-
 ?
2.4.2.7 4-amino-5-imidazolecarboxamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Homo sapiens 4-amino-5-imidazolecarboxamide ribotide + diphosphate
-
 ?
2.4.2.7 6-mercaptopurine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Homo sapiens 6-mercaptopurine ribotide + diphosphate
-
 ?
2.4.2.7 adenine + 5-phospho-alpha-D-ribose 1-diphosphate highly specific for the donor substrate Homo sapiens AMP + diphosphate
-
 ?
2.4.2.7 additional information no substrate: adenosine Homo sapiens ?
-
 ?
2.4.2.7 additional information no substrate: hypoxanthine,guanine Homo sapiens ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.2.7 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.7 additional information
-
 pI: 4.85 Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.4.2.7 7.4 9.5 broad maximum Homo sapiens