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Literature summary extracted from

  • Walter, R.D.; Koenigk, E.
    Hypoxanthine-guanine phosphoribosyltransferase and adenine phosphoribosyltransferase from Plasmodium chabaudi, purification and properties (1974), Tropenmed. Parasitol., 25, 227-235.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.8 2-amino-6-mercaptopurine competitive to hypoxanthine Plasmodium chabaudi
2.4.2.8 6-Mercaptopurine competitive to hypoxanthine Plasmodium chabaudi
2.4.2.8 6-thioguanine competitive to hypoxanthine Plasmodium chabaudi

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.7 0.005
-
 adenine
-
 Plasmodium chabaudi
2.4.2.8 0.002
-
 guanine
-
 Plasmodium chabaudi
2.4.2.8 0.0025
-
 hypoxanthine
-
 Plasmodium chabaudi

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.2.7 34000
-
-
 Plasmodium chabaudi
2.4.2.8 71000
-
-
 Plasmodium chabaudi

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.7 Plasmodium chabaudi
-
 maintained in NMRI mice
-
2.4.2.8 Plasmodium chabaudi
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.7
-
 Plasmodium chabaudi
2.4.2.8
-
 Plasmodium chabaudi

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.7 adenine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Plasmodium chabaudi AMP + diphosphate
-
 ?
2.4.2.8 guanine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Plasmodium chabaudi GMP + diphosphate
-
 ?
2.4.2.8 hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Plasmodium chabaudi IMP + diphosphate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.7 additional information
-
 pI: 4.95 Plasmodium chabaudi
2.4.2.8 additional information
-
 pI: 5.25 Plasmodium chabaudi