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Literature summary extracted from
- Characterization of the upp gene encoding uracil phosphoribosyltransferase of Escherichia coli K12 (1992), Eur. J. Biochem., 204, 51-56.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 2.4.2.9 | DNA sequence determination and analysis, gene upp belongs to purMN operon, complementation of deficient Escherichia coli strain | Escherichia coli |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.4.2.9 | dUTP | - |
Escherichia coli |  |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 2.4.2.9 | 22500 | - |
x * 22500, DNA sequence determination | Escherichia coli |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.4.2.9 | uracil + 5-phospho-alpha-D-ribose 1-diphosphate | Escherichia coli | pyrimidine salvage enzyme, no de novo synthesis of pyrmidines | UMP + diphosphate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.4.2.9 | Escherichia coli | - |
K12 | - |
| 2.4.2.9 | Escherichia coli | - |
gene upp | - |
| 2.4.2.9 | Escherichia coli | - |
enzyme expression is inducible upon uracil starvation | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 2.4.2.9 | additional information | - |
activity in different recombinant strain | Escherichia coli |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.4.2.9 | uracil + 5-phospho-alpha-D-ribose 1-diphosphate | 5-phospho-alpha-D-ribose 1-diphosphate binding site | Escherichia coli | UMP + diphosphate | - |
r | |
| 2.4.2.9 | uracil + 5-phospho-alpha-D-ribose 1-diphosphate | pyrimidine salvage enzyme, no de novo synthesis of pyrmidines | Escherichia coli | UMP + diphosphate | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 2.4.2.9 | ? | x * 22500, DNA sequence determination | Escherichia coli |
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