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Literature summary extracted from

  • Olsen, A.S.; Milman, G.
    Human hypoxanthine phosphoribosyltransferase. Purification and properties (1977), Biochemistry, 16, 2501-2505.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.2.8 26000
-
 3 * 26000, SDS-PAGE Homo sapiens
2.4.2.8 81000 83000 sedimentation equilibrium centrifugation Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.8 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.8
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.8 erythrocyte
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.2.8 17.5
-
 purified enzyme, erythrocytes Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.8 guanine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Homo sapiens GMP + diphosphate
-
 ?
2.4.2.8 hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Homo sapiens IMP + diphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.2.8 trimer 3 * 26000, SDS-PAGE Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.2.8 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.8 additional information
-
 3 charge variant forms with pIs of 5.6, 5.7 and 5.9 Homo sapiens