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Literature summary extracted from

  • Heroux, A.; White, E.L.; Ross, L.J.; Borhani, D.W.
    Crystal structures of the Toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase-GMP and -IMP complexes: comparison of purine binding interactions with the XMP complex (1999), Biochemistry, 38, 14485-14494.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.4.2.8 crystallization in complex with GMP and IMP, structure analysis Toxoplasma gondii

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.8 Toxoplasma gondii Q26997
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.4.2.8 IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate catalytic mechanism Toxoplasma gondii
a
2.4.2.8 IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate active site structure Toxoplasma gondii
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.8 guanine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Toxoplasma gondii GMP + diphosphate
-
 ?
2.4.2.8 hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Toxoplasma gondii IMP + diphosphate
-
 ?
2.4.2.8 xanthine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Toxoplasma gondii XMP + diphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.2.8 More structure determination and analysis Toxoplasma gondii
2.4.2.8 tetramer
-
 Toxoplasma gondii