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Literature summary extracted from

  • Drabikowska, A.K.
    Uridine phosphorylase from Hymenolepis diminuta (Cestoda): kinetics and inhibition by pyrimidine nucleoside analogs (1996), Acta Biochim. Pol., 43, 733-741.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.2.3 1-(1',3'-dihydroxy-2'-propoxy)methyl-5-benzyluracil i.e. DHPBU, competitive Hymenolepis diminuta
2.4.2.3 2,2'-Anhydro-5-ethyluridine 0.001 mM, competitive Hymenolepis diminuta
2.4.2.3 2,3'-anhydro-5-ethyluridine competitive Hymenolepis diminuta
2.4.2.3 tetramethylene acyclouridine
-
 Hymenolepis diminuta
2.4.2.3 uridine
-
 Hymenolepis diminuta

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.3 0.033
-
 uridine
-
 Hymenolepis diminuta
2.4.2.3 0.05
-
 ribose 1-phosphate
-
 Hymenolepis diminuta
2.4.2.3 0.204
-
 Uracil
-
 Hymenolepis diminuta
2.4.2.3 0.806
-
 phosphate
-
 Hymenolepis diminuta

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.2.3 cytoplasm
-
 Hymenolepis diminuta 5737
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.3 Hymenolepis diminuta
-
 tapeworm
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.2.3 partial Hymenolepis diminuta

Reaction

EC Number Reaction Comment Organism Reaction ID
2.4.2.3 uridine + phosphate = uracil + alpha-D-ribose 1-phosphate sequential mechanism Hymenolepis diminuta
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.3 thymidine + phosphate
-
 Hymenolepis diminuta thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
 ?
2.4.2.3 uridine + phosphate
-
 Hymenolepis diminuta uracil + alpha-D-ribose 1-phosphate
-
 r

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.3 7.5 8
-
 Hymenolepis diminuta

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.2.3 0.00007
-
 2,2'-Anhydro-5-ethyluridine
-
 Hymenolepis diminuta
2.4.2.3 0.00007
-
 1-(1',3'-dihydroxy-2'-propoxy)methyl-5-benzyluracil
-
 Hymenolepis diminuta
2.4.2.3 0.0088
-
 tetramethylene acyclouridine
-
 Hymenolepis diminuta
2.4.2.3 0.014
-
 2,3'-anhydro-5-ethyluridine
-
 Hymenolepis diminuta
2.4.2.3 0.047
-
 uridine
-
 Hymenolepis diminuta