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Literature summary extracted from

  • Farnsworth, C.C.; Seabra, M.C.; Ericsson, L.H.; Gelb, M.H.; Glomset, J.A.
    Rab geranylgeranyl transferase catalyses the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A (1994), Proc. Natl. Acad. Sci. USA, 91, 11963-11967.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.60 recombinant enzyme produced in insect cells Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.60 Rattus norvegicus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.5.1.60 geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate mechanism, recombinant enzyme/REP-1 complex catalyzes the geranylgeranylation of both adjacent cysteines in Rab1A, Rab3A and Rab5A Rattus norvegicus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.60 geranylgeranyl diphosphate + protein-cysteine
-
 Rattus norvegicus S-geranylgeranyl-protein + diphosphate
-
 ?
2.5.1.60 geranylgeranyl diphosphate + Rab1A substrate motif: -XXCC Rattus norvegicus ?
-
 ?
2.5.1.60 geranylgeranyl diphosphate + Rab3A substrate motif: -XCXC Rattus norvegicus ?
-
 ?
2.5.1.60 geranylgeranyl diphosphate + Rab5A substrate motif: -CCXX Rattus norvegicus ?
-
 ?