Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Tachibana, A.; Tanaka, T.; Taniguchi, M.; Oi, S.
    Potassium-stimulating mechanism of geranylgeranyl diphosphate synthase of Methanobacterium thermoformicicum SF-4 (1993), J. Biochem., 114, 389-392.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.5.1.29 NH4+ 50 mM, enhances activity approx. 13fold Methanothermobacter thermautotrophicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.29 diphosphate
-
Methanothermobacter thermautotrophicus
2.5.1.29 geranylgeranyl diphosphate
-
Methanothermobacter thermautotrophicus
2.5.1.29 Li+ 400 mM, 72% inhibition, slight activation at 50 mM Methanothermobacter thermautotrophicus
2.5.1.29 additional information monovalent cations at low concentrations, i.e. 50 mM, enhance activity, at high concentrations, i.e. 400 mM, they are inhibitory, except for K+ Methanothermobacter thermautotrophicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.5.1.29 KCl 200-2300 mM, enhances activity approx. 10fold Methanothermobacter thermautotrophicus
2.5.1.29 additional information monovalent cations at low concentrations, i.e. 50 mM, enhance activity, at high concentrations, i.e. 400 mM, they are inhibitory, except for K+ Methanothermobacter thermautotrophicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.29 (E,E)-farnesyl diphosphate + isopentenyl diphosphate Methanothermobacter thermautotrophicus
-
geranylgeranyl diphosphate + diphosphate
-
?
2.5.1.29 (E,E)-farnesyl diphosphate + isopentenyl diphosphate Methanothermobacter thermautotrophicus SF-4
-
geranylgeranyl diphosphate + diphosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.29 Methanothermobacter thermautotrophicus
-
SF-4
-
2.5.1.29 Methanothermobacter thermautotrophicus SF-4
-
SF-4
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.5.1.29 (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate ordered-sequential bi bi mechanism Methanothermobacter thermautotrophicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.29 (E,E)-farnesyl diphosphate + isopentenyl diphosphate
-
Methanothermobacter thermautotrophicus geranylgeranyl diphosphate + diphosphate
-
?
2.5.1.29 (E,E)-farnesyl diphosphate + isopentenyl diphosphate
-
Methanothermobacter thermautotrophicus SF-4 geranylgeranyl diphosphate + diphosphate
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.5.1.29 60
-
assay at Methanothermobacter thermautotrophicus