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Literature summary extracted from

  • Walther, M.; Holzhutter, H.G.; Kuban, R.J.; Wiesner, R.; Rathmann, J.; Kuhn, H.
    The inhibition of mammalian 15-lipoxygenases by the anti-inflammatory drug ebselen: dual-type mechanism involving covalent linkage and alteration of the iron ligand sphere (1999), Mol. Pharmacol., 56, 196-203.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.33 4-nitrocatechol IC50: 0.0046 mM Oryctolagus cuniculus
1.13.11.33 5,8,11,14-eicosatetraenoic acid IC50: 0.00012 mM Oryctolagus cuniculus
1.13.11.33 ebselen i.e. 2-phenyl-1,2-benzisoselenazol-3(2H)-one, irreversible inhibition, IC50: 0.00006 mM Oryctolagus cuniculus
1.13.11.33 linoleic acid
-
 Oryctolagus cuniculus
1.13.11.33 N,2-dihydroxybenzamide IC50: 0.057 mM Oryctolagus cuniculus
1.13.11.33 nordihydroguaiaretic acid IC50: 0.0005 mM Oryctolagus cuniculus
1.13.11.33 PD 146 176 IC50: 0.00038 mM Oryctolagus cuniculus
1.13.11.33 tert-butylhydroxyanisol IC50: 0.16 mM Oryctolagus cuniculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.13.11.33 Iron contains 0.95 mol of iron per mol of enzyme Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.33 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.33 reticulocyte
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.33 arachidonate + O2
-
 Oryctolagus cuniculus (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
1.13.11.33 linoleic acid + O2
-
 Oryctolagus cuniculus 13-hydroxylinoleic acid
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.13.11.33 0.0041
-
 linoleic acid
-
 Oryctolagus cuniculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.13.11.33 0.00006
-
 i.e. 2-phenyl-1,2-benzisoselenazol-3(2H)-one, irreversible inhibition, IC50: 0.00006 mM Oryctolagus cuniculus ebselen
1.13.11.33 0.00012
-
 IC50: 0.00012 mM Oryctolagus cuniculus 5,8,11,14-eicosatetraenoic acid
1.13.11.33 0.00038
-
 IC50: 0.00038 mM Oryctolagus cuniculus PD 146 176
1.13.11.33 0.0005
-
 IC50: 0.0005 mM Oryctolagus cuniculus nordihydroguaiaretic acid
1.13.11.33 0.0046
-
 IC50: 0.0046 mM Oryctolagus cuniculus 4-nitrocatechol
1.13.11.33 0.057
-
 IC50: 0.057 mM Oryctolagus cuniculus N,2-dihydroxybenzamide
1.13.11.33 0.16
-
 IC50: 0.16 mM Oryctolagus cuniculus tert-butylhydroxyanisol