Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Miller, J.E.; Litwack, G.
    Purification, properties, and identity of liver mitochondrial tyrosine aminotransferase (1971), J. Biol. Chem., 246, 3234-3240.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.6.1.5 spontaneous crystallization when enzyme concentration is about 10 mg protein per ml Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.5 alpha-Methyl-L-aspartate with L-tyrosine and 2-oxoglutarate or oxaloacetate as substrates Rattus norvegicus
2.6.1.5 beta-Methyl-L-aspartate with L-tyrosine and 2-oxoglutarate or oxaloacetate as substrates Rattus norvegicus
2.6.1.5 D-Aspartate weak inhibition Rattus norvegicus
2.6.1.5 L-aspartate with L-tyrosine and 2-oxoglutarate or oxaloacetate as substrates Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.6.1.5 mitochondrion
-
Rattus norvegicus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.6.1.5 90000
-
amino acid composition and gel filtration Rattus norvegicus
2.6.1.5 114000
-
sedimentation analysis Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.5 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.5 partial, using Sephadex chromatography and isoelectrofocusing Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.5 liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.6.1.5 0.155
-
-
Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.5 (4-chlorophenyl)alanine + 2-oxoglutarate 17% of the activity with L-tyrosine Rattus norvegicus 3-(3-chlorophenyl)-2-oxopropanoate + L-glutamate
-
?
2.6.1.5 3,4-dihydroxyphenylalanine + 2-oxoglutarate 85% of the activity than with L-tyrosine Rattus norvegicus 3-(3,4-dihydroxyphenyl)-2-oxopropanoate + L-glutamate
-
?
2.6.1.5 3-iodotyrosine + 2-oxoglutarate 84% of the activity than with L-tyrosine Rattus norvegicus 3-(4-hydroxy-3-iodophenyl)-2-oxopropanoate + L-glutamate
-
?
2.6.1.5 3-methoxytyrosine + 2-oxoglutarate 22% of the activity with L-tyrosine Rattus norvegicus 3-(3-methoxy-4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
-
?
2.6.1.5 4-hydroxyphenylpyruvate + L-aspartate 35% of the activity with L-glutamate Rattus norvegicus L-tyrosine + oxaloacetate
-
r
2.6.1.5 L-asparagine + 2-oxoglutarate 15% of the activity with L-tyrosine Rattus norvegicus 2-oxosuccinamate + L-glutamate
-
?
2.6.1.5 L-aspartate + 2-oxoglutarate higher activity than with L-tyrosine Rattus norvegicus oxaloacetate + L-glutamate
-
?
2.6.1.5 L-cysteine + 2-oxoglutarate higher activity than with L-tyrosine Rattus norvegicus 3-mercapto-2-oxopropanoate + L-glutamate
-
?
2.6.1.5 L-ethionine + 2-oxoglutarate 17% of the activity than with L-tyrosine Rattus norvegicus 4-ethylsulfanyl-2-oxobutanoate + L-glutamate
-
?
2.6.1.5 L-methionine + 2-oxoglutarate 20% of the activity than with L-tyrosine Rattus norvegicus 4-methylsulfanyl-2-oxobutanoate + L-glutamate
-
?
2.6.1.5 L-phenylalanine + 2-oxoglutarate higher rate than with L-tyrosine Rattus norvegicus phenylpyruvate + L-glutamate
-
?
2.6.1.5 L-tyrosine + 2-oxoglutarate
-
Rattus norvegicus 4-hydroxyphenylpyruvate + L-glutamate
-
r
2.6.1.5 L-tyrosine + oxaloacetate
-
Rattus norvegicus 4-hydroxyphenylpyruvate + L-aspartate
-
r
2.6.1.5 tryptophan + 2-oxoglutarate 62% of the activity than with L-tyrosine Rattus norvegicus 3-indole-2-oxopropanoate + L-glutamate
-
?

Synonyms

EC Number Synonyms Comment Organism
2.6.1.5 More the mitochondrial enzyme may be identical with EC 2.6.1.1 and with EC 2.6.1.57 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.6.1.5 37
-
assay at Rattus norvegicus