Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Jacoby, G.A.; La Du, B.N.
    Studies on the specificity of tyrosine-alpha-ketoglutarate transaminase (1964), J. Biol. Chem., 239, 419-424.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.5 (4-hydroxyphenyl)acetic acid 74% inhibition with tyrosine at 3 mM and (4-hydroxyphenyl)acetic acid at 12 mM Rattus norvegicus
2.6.1.5 3,4-dihydroxyphenylalanine
-
 Rattus norvegicus
2.6.1.5 3-(3,4-Dihydroxyphenyl)-2-methylalanine
-
 Rattus norvegicus
2.6.1.5 3-methoxydopamine
-
 Rattus norvegicus
2.6.1.5 3-Methoxytyrosine
-
 Rattus norvegicus
2.6.1.5 5-hydroxyindole acetic acid 55% inhibition with tyrosine at 3 mM and 5-hydroxyindole acetic acid at 12 mM Rattus norvegicus
2.6.1.5 5-hydroxytryptophan 30% inhibition with tyrosine at 3 mM and 5-hydroxytryptophan at 12 mM Rattus norvegicus
2.6.1.5 alpha-Methyltyrosine
-
 Rattus norvegicus
2.6.1.5 D-tyrosine 9% inhibition with tyrosine at 3 mM and D-tyrosine at 12 mM Rattus norvegicus
2.6.1.5 dihydroxymandelic acid 65% inhibition with tyrosine at 3 mM and dihydroxymandelic acid at 3 mM Rattus norvegicus
2.6.1.5 dihydroxyphenylacetic acid 88% inhibition with tyrosine at 3 mM and dihydroxyphenylacetic acid at 3 mM Rattus norvegicus
2.6.1.5 dopamine 100% inhibition with tyrosine at 3 mM and dopamine at 12 mM Rattus norvegicus
2.6.1.5 homovanillic acid
-
 Rattus norvegicus
2.6.1.5 indole-3-acetic acid 42% inhibition with tyrosine at 3 mM and indole-3-acetic acid at 12 mM Rattus norvegicus
2.6.1.5 indole-3-butyric acid 71% inhibition with tyrosine at 3 mM and indole-3-butyric acid at 12 mM Rattus norvegicus
2.6.1.5 Indole-3-propionic acid 48% inhibition with tyrosine at 3 mM and indole-3-propionic acid at 12 mM Rattus norvegicus
2.6.1.5 norepinephrine competitive inhibition Rattus norvegicus
2.6.1.5 normetanephrine
-
 Rattus norvegicus
2.6.1.5 phenylacetic acid 30% inhibition with tyrosine at 3 mM and phenylacetic acid at 12 mM Rattus norvegicus
2.6.1.5 Phenylethylamine 80% inhibition with tyrosine at 3 mM and phenylethylamine at 12 mM Rattus norvegicus
2.6.1.5 serotonin 37% inhibition with tyrosine at 3 mM and serotonin at 12 mM Rattus norvegicus
2.6.1.5 tyramine 13% inhibition with tyrosine at 3 mM and tyramine at 12 mM Rattus norvegicus
2.6.1.5 vanillylmandelic acid 51% inhibition with tyrosine at 3 mM and vanillylmandelic acid at 3 mM Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.5 15
-
 L-tyrosine pH 7.9, 37°C Rattus norvegicus
2.6.1.5 26
-
 3,4-dihydroxyphenylalanine pH 7.9, 37°C Rattus norvegicus
2.6.1.5 30
-
 tryptophan pH 7.9, 37°C Rattus norvegicus
2.6.1.5 80
-
 phenylalanine pH 7.9, 37°C Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.5 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.5 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.6.1.5 additional information
-
 effect of induction with hydrocortisone on activity Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.5 (2-aminophenyl)alanine + 2-oxoglutarate 10% of the activity that with L-tyrosine Rattus norvegicus 3-(4-aminophenyl)-2-oxopropanoate + L-glutamate
-
 ?
2.6.1.5 (3-fluorophenyl)alanine + 2-oxoglutarate 4% of the activity that with L-tyrosine Rattus norvegicus 3-(3-fluorophenyl)-2-oxopropanoate + L-glutamate
-
 ?
2.6.1.5 (4-fluorophenyl)alanine + 2-oxoglutarate 7.9% of the activity that with L-tyrosine Rattus norvegicus 3-(4-fluorophenyl)-2-oxopropanoate + L-glutamate
-
 ?
2.6.1.5 3,4-dihydroxyphenylalanine + 2-oxoglutarate
-
 Rattus norvegicus 3-(3,4-dihydroxyphenyl)-2-oxopropanoate + L-glutamate
-
 ?
2.6.1.5 3-aminotyrosine + 2-oxoglutarate 16% of the activity than with L-tyrosine Rattus norvegicus 3-(3-amino-4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
-
 ?
2.6.1.5 3-iodotyrosine + 2-oxoglutarate as effective as L-tyrosine Rattus norvegicus 3-(4-hydroxy-3-iodophenyl)-2-oxopropanoate + L-glutamate
-
 ?
2.6.1.5 L-phenylalanine + 2-oxoglutarate lower activity than with L-tyrosine Rattus norvegicus phenylpyruvate + L-glutamate
-
 ?
2.6.1.5 L-tyrosine + 2-oxoglutarate maximal activity with L-tyrosine Rattus norvegicus 4-hydroxyphenylpyruvate + L-glutamate
-
 ?
2.6.1.5 tryptophan + 2-oxoglutarate
-
 Rattus norvegicus 3-indole-2-oxopropanoate + L-glutamate
-
 ?