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Literature summary extracted from

  • Echetebu, C.O.; Ifem, F.M.; Echetebu, Z.O.
    Hepatic tyrosine aminotransferase from the rainbow lizard Agama agama: purification and some properties (1987), Biochimie, 69, 223-230.
    View publication on PubMed

General Stability

EC Number General Stability Organism
2.6.1.5 2-oxoglutarate protects against thermal inactivation Agama agama
2.6.1.5 pyridoxal 5'-phosphate protects against thermal inactivation Agama agama
2.6.1.5 sensitive to SH inactivation Agama agama

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.5 Ag2+
-
 Agama agama
2.6.1.5 Ca2+
-
 Agama agama
2.6.1.5 Hg2+
-
 Agama agama
2.6.1.5 L-glutamate competitive inhibition Agama agama
2.6.1.5 Mn2+
-
 Agama agama
2.6.1.5 Zn2+
-
 Agama agama

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.5 additional information
-
 additional information
-
 Agama agama

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.6.1.5 cytoplasm
-
 Agama agama 5737
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.6.1.5 130000
-
-
 Agama agama

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.5 Agama agama
-
 rainbow lizard
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.5 partial, using ammonium sulfate precipitation and several chromatographic steps Agama agama

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.5 liver
-
 Agama agama
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.6.1.5 additional information
-
-
 Agama agama

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.5 L-tyrosine + 2-oxoglutarate highly specific for: L-tyrosine Agama agama 4-hydroxyphenylpyruvate + L-glutamate
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.6.1.5 additional information
-
 2-oxoglutarate protects against thermal inactivation Agama agama
2.6.1.5 additional information
-
 pyridoxal 5'-phosphate protects against thermal inactivation Agama agama

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.6.1.5 7.6
-
-
 Agama agama

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.6.1.5 additional information
-
 additional information inhibition due to L-glutamate Agama agama