EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.1.1 | Hex A and Hex B are products of the same structural gene, but differ by epigenetic or posttranslational modifications, the gene is mapped on the X chromosome, Hex C is mapped on the second chromosome, Hex C1 and C2 are genetic variants | Drosophila melanogaster |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.1 | additional information | - |
additional information | - |
Drosophila melanogaster |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.7.1.1 | 40000 | 50000 | Hex A, Hex B and Hex C | Drosophila melanogaster |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.1 | Drosophila melanogaster | - |
Samarkand, adult | - |
2.7.1.1 | Drosophila melanogaster | - |
multiple forms: Hex A, Hex B and Hex C | - |
2.7.1.1 | Drosophila melanogaster Samarkand | - |
Samarkand, adult | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.1.1 | purification of 2 enzyme forms: Hex A: 1370fold, Hex C2: 600fold | Drosophila melanogaster |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.1.1 | larva | Hex B predominates in larval extract, Hex A is completely absent | Drosophila melanogaster | - |
2.7.1.1 | whole body | adult, Hex A, Hex B and Hex C | Drosophila melanogaster | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.7.1.1 | 60 | - |
enzyme form Hex C, at 25°C, pH 8 | Drosophila melanogaster |
2.7.1.1 | 137 | - |
enzyme form Hex A, at 25°C, pH 8 | Drosophila melanogaster |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.1 | 2'-dATP + D-glucose | Hex A: 73% of the activity with ATP, Hex B: 76% of the activity with ATP, Hex C: 80% of the activity with ATP | Drosophila melanogaster | 2'-dADP + D-glucose 6-phosphate | - |
? | |
2.7.1.1 | ATP + 2-deoxy-D-glucose | Hex A: 93% of the activity with glucose, Hex B: 51% of the activity with glucose, Hex C: 48% of the activity with glucose | Drosophila melanogaster | ADP + 2-deoxy-D-glucose 6-phosphate | - |
? | |
2.7.1.1 | ATP + 2-deoxy-D-glucose | Hex A: 93% of the activity with glucose, Hex B: 51% of the activity with glucose, Hex C: 48% of the activity with glucose | Drosophila melanogaster Samarkand | ADP + 2-deoxy-D-glucose 6-phosphate | - |
? | |
2.7.1.1 | CTP + D-glucose | Hex B: 5% of the activity with ATP, Hex C: 11% of the activity with ATP, not Hex A | Drosophila melanogaster | CDP + D-glucose 6-phosphate | - |
? | |
2.7.1.1 | D-fructose + ATP | Hex A: 50% of the activity with glucose, Hex B: 41% of the activity with glucose, Hex C: 134% of the activity with glucose | Drosophila melanogaster | ADP + D-fructose 6-phosphate | - |
? | |
2.7.1.1 | D-fructose + ATP | Hex A: 50% of the activity with glucose, Hex B: 41% of the activity with glucose, Hex C: 134% of the activity with glucose | Drosophila melanogaster Samarkand | ADP + D-fructose 6-phosphate | - |
? | |
2.7.1.1 | D-glucosamine + ATP | Hex A: 19% of the activity with glucose, Hex C: 44% of the activity with glucose, not Hex B | Drosophila melanogaster | ADP + D-glucosamine 6-phosphate | - |
? | |
2.7.1.1 | D-glucosamine + ATP | Hex A: 19% of the activity with glucose, Hex C: 44% of the activity with glucose, not Hex B | Drosophila melanogaster Samarkand | ADP + D-glucosamine 6-phosphate | - |
? | |
2.7.1.1 | D-glucose + ATP | the binding of glucose does not depend on ATP, and vice versa | Drosophila melanogaster | ADP + D-glucose 6-phosphate | - |
? | |
2.7.1.1 | D-glucose + ATP | the binding of glucose does not depend on ATP, and vice versa | Drosophila melanogaster Samarkand | ADP + D-glucose 6-phosphate | - |
? | |
2.7.1.1 | D-mannose + ATP | Hex A: 100% of the activity with glucose, Hex B: 98% of the activity with glucose, Hex C: 44% of the activity with glucose | Drosophila melanogaster | ADP + D-mannose 6-phosphate | - |
? | |
2.7.1.1 | D-mannose + ATP | Hex A: 100% of the activity with glucose, Hex B: 98% of the activity with glucose, Hex C: 44% of the activity with glucose | Drosophila melanogaster Samarkand | ADP + D-mannose 6-phosphate | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.7.1.1 | monomer | - |
Drosophila melanogaster |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.7.1.1 | 25 | - |
assay at | Drosophila melanogaster |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.1 | ATP | - |
Drosophila melanogaster |
EC Number | Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|---|
2.7.1.1 | Drosophila melanogaster | Hex C1, isoelectric focusing | - |
6.1 |
2.7.1.1 | Drosophila melanogaster | Hex C2, isoelectric focusing | - |
6.4 |