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Literature summary extracted from

  • Miller, S.P.; Chen, R.; Karschnia, E.J.; Romfo, C.; Dean, A.; LaPorte, D.C.
    Locations of the regulatory sites for isocitrate dehydrogenase kinase/phosphatase (2000), J. Biol. Chem., 275, 833-839.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.5 3-phosphoglycerate
-
 Escherichia coli
2.7.11.5 AMP
-
 Escherichia coli
2.7.11.5 DL-isocitrate inhibits only kinase activity Escherichia coli
2.7.11.5 NADPH inhibits both IDH kinase and IDH phosphatase Escherichia coli
2.7.11.5 pyruvate
-
 Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.11.5 0.0009
-
 [isocitrate dehydrogenase (NADP+)]N15L pH 7.5, 37°C Escherichia coli
2.7.11.5 0.0017
-
 [isocitrate dehydrogenase (NADP+)] pH 7.5, 37°C Escherichia coli
2.7.11.5 0.02
-
 [isocitrate dehydrogenase (NADP+)]IS pH 7.5, 37°C Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.5 ATP + [isocitrate dehydrogenase (NADP+)] Escherichia coli
-
 ADP + [isocitrate dehydrogenase (NADP+)] phosphate
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.5 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.5 ATP + [isocitrate dehydrogenase (NADP+)]
-
 Escherichia coli ADP + [isocitrate dehydrogenase (NADP+)] phosphate
-
 r
2.7.11.5 ATP + [isocitrate dehydrogenase (NADP+)]IS
-
 Escherichia coli ADP + [isocitrate dehydrogenase (NADP+)]IS phosphate
-
 ?
2.7.11.5 ATP + [isocitrate dehydrogenase (NADP+)]N115L
-
 Escherichia coli ADP + [isocitrate dehydrogenase (NADP+)]N115L phosphate
-
 ?
2.7.11.5 ATP + [isocitrate dehydrogenase (NADP+)]N15L
-
 Escherichia coli [isocitrate dehydrogenase (NADP+)]N15L phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.5 isocitrate dehydrogenase kinase/phosphatase
-
 Escherichia coli

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.11.5 0.008
-
 AMP pH 7.5, 37°C Escherichia coli
2.7.11.5 0.011
-
 isocitrate pH 7.5, 37°C, mutant AceK4, kinase activity Escherichia coli
2.7.11.5 0.015
-
 isocitrate pH 7.5, 37°C, mutant AceK3, kinase activity Escherichia coli
2.7.11.5 0.016
-
 isocitrate pH 7.5, 37°C, wild-type, kinase activity Escherichia coli
2.7.11.5 0.02
-
 AMP pH 7.5, 37°C, mutant AceK4, kinase activity Escherichia coli
2.7.11.5 0.058
-
 NADPH pH 7.5, 37°C, mutant AceK4, kinase activity Escherichia coli
2.7.11.5 0.073
-
 NADPH pH 7.5, 37°C, mutant AceK3, kinase activity Escherichia coli
2.7.11.5 0.082
-
 NADPH pH 7.5, 37°C, wild-type, kinase activity Escherichia coli
2.7.11.5 0.17
-
 AMP pH 7.5, 37°C, mutant AceK3, kinase activity Escherichia coli
2.7.11.5 0.2
-
 pyruvate pH 7.5, 37°C, wild-type, kinase activity Escherichia coli
2.7.11.5 1
-
 pyruvate pH 7.5, 37°C, mutant AceK4, kinase activity Escherichia coli
2.7.11.5 1
-
 3-phosphoglycerate pH 7.5, 37°C, wild-type, kinase activity Escherichia coli
2.7.11.5 4
-
 3-phosphoglycerate pH 7.5, 37°C, mutant AceK4, kinase activity Escherichia coli
2.7.11.5 4
-
 pyruvate pH 7.5, 37°C, mutant AceK3, kinase activity Escherichia coli
2.7.11.5 20
-
 3-phosphoglycerate pH 7.5, 37°C, mutant AceK3, kinase activity Escherichia coli