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Literature summary extracted from

  • Miller, R.L.; Adamczyk, D.L.; Miller, W.H.
    Adenosine kinase from rabbit liver. I. Purification by affinity chromatography and properties (1979), J. Biol. Chem., 254, 2339-2345.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.20 adenosine kinetics Oryctolagus cuniculus
2.7.1.20 ATP
-
Oryctolagus cuniculus
2.7.1.20 EDTA at high concentrations Oryctolagus cuniculus
2.7.1.20 Mg2+
-
Oryctolagus cuniculus
2.7.1.20 additional information no inhibition by PMSF, EGTA Oryctolagus cuniculus
2.7.1.20 p-hydroxymercuribenzoate DTT reverses Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.20 0.00015 0.0005 adenosine pH 6.8, 30ºC Oryctolagus cuniculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.20 cytosol
-
Oryctolagus cuniculus 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.20 Ba2+ no activation Oryctolagus cuniculus
2.7.1.20 Ca2+ activation Oryctolagus cuniculus
2.7.1.20 Mg2+ requirement Oryctolagus cuniculus
2.7.1.20 Mn2+ can partially substitute for Mg2+ Oryctolagus cuniculus
2.7.1.20 Mn2+ activation Oryctolagus cuniculus
2.7.1.20 additional information emission spectral analysis show that enzyme contains tightly bound divalent metal ions Oryctolagus cuniculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.20 34500
-
gel filtration Oryctolagus cuniculus
2.7.1.20 51000
-
1 * 51000, SDS-PAGE Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.20 ATP + adenosine Oryctolagus cuniculus involved in phosphorylation of many pharmacological active purine nucleosides ADP + AMP
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.20 Oryctolagus cuniculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.20 gel filtration and affinity chromatography Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.20 liver
-
Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.20 1.75 2.23
-
Oryctolagus cuniculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.20 ATP + adenosine specificity Oryctolagus cuniculus ADP + AMP
-
?
2.7.1.20 ATP + adenosine best substrates Oryctolagus cuniculus ADP + AMP
-
?
2.7.1.20 ATP + adenosine ATP-analogues are also substrates Oryctolagus cuniculus ADP + AMP
-
?
2.7.1.20 ATP + adenosine involved in phosphorylation of many pharmacological active purine nucleosides Oryctolagus cuniculus ADP + AMP
-
?
2.7.1.20 CTP + adenosine CTP is a poor substrate Oryctolagus cuniculus CDP + AMP
-
?
2.7.1.20 GTP + adenosine
-
Oryctolagus cuniculus GDP + AMP
-
?

Subunits

EC Number Subunits Comment Organism
2.7.1.20 monomer 1 * 51000, SDS-PAGE Oryctolagus cuniculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.20 30
-
assay at Oryctolagus cuniculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.20 additional information
-
the pH-optimum is a function of the adenosine concentration Oryctolagus cuniculus
2.7.1.20 additional information
-
the pH-optimum is a function of the ATP/Mg2+ ratio Oryctolagus cuniculus
2.7.1.20 4.8
-
below, ATP/Mg2+ ratio: 0.1 Oryctolagus cuniculus
2.7.1.20 5.2
-
ATP/Mg2+ ratio: 1 Oryctolagus cuniculus
2.7.1.20 5.5
-
ATP/Mg2+ ratio: 10 Oryctolagus cuniculus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.7.1.20 4.6 5.8 about half-maximal activity at pH 4.6 and pH 5.8, ATP/Mg2+ ratio: 1 Oryctolagus cuniculus
2.7.1.20 5.2 6.4 about half-maximal activity at pH 5.2 and pH 6.4, ATP/Mg2+ ratio: 10 Oryctolagus cuniculus