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Literature summary extracted from

  • Xu, Z.H.; Otterness, D.M.; Freimuth, R.R.; Carlini, E.J.; Wood, T.C.; Mitchell, S.; Moon, E.; Kim, U.J.; Xu, J.P.; Siciliano, M.J.; Weinshilboum, R.M.
    Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1) and PAPSS2: gene cloning, characterization and chromosomal localization (2000), Biochem. Biophys. Res. Commun., 268, 437-444.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.25 NaClO3 6.57 mM, 50% inhibition of brain PAPSS activity, 3.26 mM, 50% inhibition of liver PAPSS Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.25 cytosol
-
 Homo sapiens 5829
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.25 Homo sapiens
-
 isoforms PAPSS 1 and PAPSS 2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.25 brain major isoform PAPSS 2 Homo sapiens
-
2.7.1.25 liver major isoform PAPSS1 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.25 ATP + adenosine 5-phosphosulfate i.e. adenylylsulfate or APS Homo sapiens ADP + 3'-phosphoadenosine 5'-phosphosulfate i.e. 3'-phosphoadenylylsulfate or PAPS, via a phosphorylated enzyme intermediate ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.25 PAPS 2
-
 Homo sapiens
2.7.1.25 PAPSS 1
-
 Homo sapiens