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Literature summary extracted from

  • Renosto, F.; Martin, R.L.; Wailes, L.M.; Daley, L.A.; Segel, I.H.
    Regulation of inorganic sulfate activation in filamentous fungi. Allosteric inhibition of ATP sulfurylase by 3-phosphoadenosine-5-phosphosulfate (1990), J. Biol. Chem., 265, 10300-10308.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.7.4 FSO3- activates in presence of 0.15 mM of 3'-phosphoadenosine-5'-phosphate Penicillium chrysogenum
2.7.7.4 S2O32- activates SO42–dependent reaction in presence of 0.15 mM of 3'-phosphoadenosine-5'-phosphate Penicillium chrysogenum

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.4 3'-phosphoadenosine-5'-phosphate strong Aspergillus nidulans
2.7.7.4 3'-phosphoadenosine-5'-phosphate strong Neurospora crassa
2.7.7.4 3'-phosphoadenosine-5'-phosphate strong Penicillium chrysogenum
2.7.7.4 3'-phosphoadenosine-5'-phosphate strong Penicillium duponti
2.7.7.4 3'-phosphoadenosine-5'-phosphate
-
 Spinacia oleracea
2.7.7.4 3'-phosphoadenosine-5'-phosphosulfate
-
 Penicillium chrysogenum
2.7.7.4 3'-phosphoadenosine-5'-phosphosulfate
-
 Spinacia oleracea
2.7.7.4 FSO3- inhibition in absence of 3'-phosphoadenosine-5'-phosphate Penicillium chrysogenum
2.7.7.4 FSO3-
-
 Penicillium duponti
2.7.7.4 FSO3-
-
 Rattus norvegicus
2.7.7.4 MgATP2-
-
 Penicillium chrysogenum
2.7.7.4 MoO42-
-
 Penicillium chrysogenum
2.7.7.4 S2O32- 1 mM, 62% inhibition Penicillium chrysogenum
2.7.7.4 S2O32-
-
 Penicillium duponti
2.7.7.4 S2O32-
-
 Rattus norvegicus
2.7.7.4 SO32- 1 mM, 10-25% inhibition Penicillium chrysogenum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.7.4 0.023
-
 ATP pH 8.0, 30°C, reaction with MoO42- Penicillium chrysogenum
2.7.7.4 0.023
-
 ATP ATP in form of MgATP2- Penicillium chrysogenum
2.7.7.4 0.093
-
 MoO42- pH 8.0, 30°C Penicillium chrysogenum

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.7.4 48000
-
 x * 48000, SDS-PAGE Spinacia oleracea
2.7.7.4 60000
-
 x * 60000, SDS-PAGE Saccharomyces cerevisiae
2.7.7.4 62000
-
 x * 62000, SDS-PAGE Rattus norvegicus
2.7.7.4 63000
-
 x * 63000, SDS-PAGE Neurospora crassa
2.7.7.4 65000
-
 x * 65000, SDS-PAGE Aspergillus nidulans
2.7.7.4 66000
-
 x * 66000, SDS-PAGE Penicillium duponti
2.7.7.4 67000
-
 x * 67000, SDS-PAGE Penicillium chrysogenum

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.4 Aspergillus nidulans
-
-
-
2.7.7.4 Neurospora crassa
-
-
-
2.7.7.4 Penicillium chrysogenum
-
-
-
2.7.7.4 Penicillium duponti
-
-
-
2.7.7.4 Rattus norvegicus
-
-
-
2.7.7.4 Saccharomyces cerevisiae
-
-
-
2.7.7.4 Spinacia oleracea
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.4 ATP + MoO42-
-
 Penicillium chrysogenum AMP + adenylylmolybdate
-
 ?
2.7.7.4 ATP + sulfate
-
 Rattus norvegicus diphosphate + adenylylsulfate
-
 r
2.7.7.4 ATP + sulfate
-
 Saccharomyces cerevisiae diphosphate + adenylylsulfate
-
 r
2.7.7.4 ATP + sulfate
-
 Aspergillus nidulans diphosphate + adenylylsulfate
-
 r
2.7.7.4 ATP + sulfate
-
 Neurospora crassa diphosphate + adenylylsulfate
-
 r
2.7.7.4 ATP + sulfate
-
 Penicillium chrysogenum diphosphate + adenylylsulfate
-
 r
2.7.7.4 ATP + sulfate
-
 Spinacia oleracea diphosphate + adenylylsulfate
-
 r
2.7.7.4 ATP + sulfate
-
 Penicillium duponti diphosphate + adenylylsulfate
-
 r
2.7.7.4 ATP + sulfate
-
 Penicillium chrysogenum diphosphate + adenylyl sulfate
-
 r

Subunits

EC Number Subunits Comment Organism
2.7.7.4 ? x * 62000, SDS-PAGE Rattus norvegicus
2.7.7.4 ? x * 48000, SDS-PAGE Spinacia oleracea
2.7.7.4 ? x * 60000, SDS-PAGE Saccharomyces cerevisiae
2.7.7.4 ? x * 66000, SDS-PAGE Penicillium duponti
2.7.7.4 ? x * 67000, SDS-PAGE Penicillium chrysogenum
2.7.7.4 ? x * 63000, SDS-PAGE Neurospora crassa
2.7.7.4 ? x * 65000, SDS-PAGE Aspergillus nidulans

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.7.4 0.000057
-
 3'-phosphoadenosine-5'-phosphosulfate pH 8.0, 30°C, competitive with MgATP2-, at 0.1 mM MoO42- Spinacia oleracea
2.7.7.4 0.000063
-
 3'-phosphoadenosine-5'-phosphosulfate pH 8.0, 30°C, at 0.1 mM MoO42- Penicillium chrysogenum
2.7.7.4 0.00007
-
 3'-phosphoadenosine-5'-phosphosulfate pH 8.0, 30°C, competitive with MoO42-, at 0.05 mM MoO42- Spinacia oleracea
2.7.7.4 0.00008
-
 3'-phosphoadenosine-5'-phosphosulfate pH 8.0, 30°C, at 0.05 mM MgATP2- Penicillium chrysogenum
2.7.7.4 0.0004
-
 3'-phosphoadenosine-5'-phosphosulfate pH 8.0, 30°C, at 20 mM MoO42- Penicillium chrysogenum
2.7.7.4 0.0004
-
 3'-phosphoadenosine-5'-phosphosulfate at 5 mM MgATP2- Penicillium chrysogenum
2.7.7.4 0.5
-
 MgATP2- pH 8.0, 30°C Penicillium chrysogenum
2.7.7.4 2.02
-
 MoO42- pH 8.0, 30°C Penicillium chrysogenum