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Literature summary extracted from

  • Deana, R.
    Substrate specificity of a dicarboxyl-CoA: dicarboxylic acid coenzyme A transferase from rat liver mitochondria (1992), Biochem. Int., 26, 767-773.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.3.13 0.07
-
glutaryl-CoA pH 7.8, 30°C, cosubstrate adipate Rattus norvegicus
2.8.3.13 0.07
-
adipyl-CoA pH 7.8, 30°C, cosubstrate glutarate Rattus norvegicus
2.8.3.13 0.11
-
adipyl-CoA pH 7.8, 30°C, cosubstrate succinate Rattus norvegicus
2.8.3.13 0.13
-
malonyl-CoA pH 7.8, 30°C, cosubstrate glutarate Rattus norvegicus
2.8.3.13 0.15
-
succinyl-CoA pH 7.8, 30°C, cosubstrate glutarate Rattus norvegicus
2.8.3.13 0.16
-
adipyl-CoA pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate Rattus norvegicus
2.8.3.13 0.18
-
glutaryl-CoA pH 7.8, 30°C, cosubstrate succinate Rattus norvegicus
2.8.3.13 0.18
-
3-hydroxy-3-methylglutaryl-CoA pH 7.8, 30°C, cosubstrate adipate, reverse reaction Rattus norvegicus
2.8.3.13 0.18
-
Glutarate pH 7.8, 30°C, cosubstrate adipylCoA Rattus norvegicus
2.8.3.13 0.26
-
succinyl-CoA pH 7.8, 30°C, cosubstrate adipate Rattus norvegicus
2.8.3.13 0.26
-
Glutarate pH 7.8, 30°C, cosubstrate malonylCoA Rattus norvegicus
2.8.3.13 0.27
-
glutaryl-CoA pH 7.8, 30°C, cosubstrate malonate Rattus norvegicus
2.8.3.13 0.28
-
succinyl-CoA pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate Rattus norvegicus
2.8.3.13 0.33
-
malonyl-CoA pH 7.8, 30°C, cosubstrate adipate Rattus norvegicus
2.8.3.13 0.38
-
adipyl-CoA pH 7.8, 30°C, cosubstrate malonate Rattus norvegicus
2.8.3.13 0.39
-
3-hydroxy-3-methylglutaryl-CoA pH 7.8, 30°C, cosubstrate succinate or glutarate, reverse reaction Rattus norvegicus
2.8.3.13 0.39
-
adipate pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA , reverse reaction Rattus norvegicus
2.8.3.13 0.4
-
adipyl-CoA pH 7.8, 30°C, cosubstrate methylmalonate Rattus norvegicus
2.8.3.13 0.45
-
glutaryl-CoA pH 7.8, 30°C, cosubstrate methylmalonate Rattus norvegicus
2.8.3.13 0.45
-
Glutarate pH 7.8, 30°C, cosubstrate succinylCoA Rattus norvegicus
2.8.3.13 0.5
-
Glutarate pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA Rattus norvegicus
2.8.3.13 0.5
-
succinate pH 7.8, 30°C, cosubstrate glutarylCoA Rattus norvegicus
2.8.3.13 0.52
-
malonyl-CoA pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate Rattus norvegicus
2.8.3.13 0.55
-
malonyl-CoA pH 7.8, 30°C, cosubstrate succinate Rattus norvegicus
2.8.3.13 0.62
-
3-hydroxy-3-methylglutaryl-CoA pH 7.8, 30°C, cosubstrate methylmalonate, reverse reaction Rattus norvegicus
2.8.3.13 0.65
-
methylmalonyl-CoA pH 7.8, 30°C, cosubstrate malonate Rattus norvegicus
2.8.3.13 0.68
-
succinate pH 7.8, 30°C, cosubstrate malonylCoA Rattus norvegicus
2.8.3.13 0.7
-
malonyl-CoA pH 7.8, 30°C, cosubstrate methylmalonate Rattus norvegicus
2.8.3.13 0.72
-
adipate pH 7.8, 30°C, cosubstrate glutaryl-CoA Rattus norvegicus
2.8.3.13 0.72
-
methylmalonyl-CoA pH 7.8, 30°C, cosubstrate glutarate or adipate Rattus norvegicus
2.8.3.13 0.73
-
glutaryl-CoA pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate Rattus norvegicus
2.8.3.13 0.74
-
methylmalonyl-CoA pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutarate Rattus norvegicus
2.8.3.13 0.75
-
succinylCoA pH 7.8, 30°C, cosubstrate malonate Rattus norvegicus
2.8.3.13 0.76
-
3-hydroxy-3-methylglutarate pH 7.8, 30°C, cosubstrate adipyl-CoA Rattus norvegicus
2.8.3.13 0.83
-
adipate pH 7.8, 30°C, cosubstrate malonylCoA Rattus norvegicus
2.8.3.13 0.83
-
succinyl-CoA pH 7.8, 30°C, cosubstrate methylmalonate Rattus norvegicus
2.8.3.13 0.84
-
Glutarate pH 7.8, 30°C, cosubstrate methylmalonylCoA Rattus norvegicus
2.8.3.13 0.87
-
methylmalonyl-CoA pH 7.8, 30°C, cosubstrate succinate Rattus norvegicus
2.8.3.13 0.88
-
succinate pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA, reverse reaction Rattus norvegicus
2.8.3.13 0.95
-
succinate pH 7.8, 30°C, cosubstrate adipyl-CoA Rattus norvegicus
2.8.3.13 1.01
-
malonate pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA , reverse reaction Rattus norvegicus
2.8.3.13 1.2
-
succinate pH 7.8, 30°C, cosubstrate methylmalonyl-CoA Rattus norvegicus
2.8.3.13 1.25
-
3-hydroxy-3-methylglutarate pH 7.8, 30°C, cosubstrate glutaryl-CoA Rattus norvegicus
2.8.3.13 1.32
-
adipate pH 7.8, 30°C, cosubstrate succinylCoA Rattus norvegicus
2.8.3.13 1.42
-
3-hydroxy-3-methylglutarate pH 7.8, 30°C, cosubstrate succinyl-CoA Rattus norvegicus
2.8.3.13 1.51
-
adipate pH 7.8, 30°C, cosubstrate methylmalonyl-CoA Rattus norvegicus
2.8.3.13 1.55
-
malonate pH 7.8, 30°C, cosubstrate glutaryl-CoA Rattus norvegicus
2.8.3.13 1.63
-
malonate pH 7.8, 30°C, cosubstrate succinyl-CoA or methylmalonyl-CoA Rattus norvegicus
2.8.3.13 1.71
-
malonate pH 7.8, 30°C, cosubstrate adipyl-CoA Rattus norvegicus
2.8.3.13 1.8
-
3-hydroxy-3-methylglutarate pH 7.8, 30°C, cosubstrate malonyl-CoA Rattus norvegicus
2.8.3.13 1.95
-
methylmalonate pH 7.8, 30°C, cosubstrate 3-hydroxy-3-methylglutaryl-CoA, reverse reaction Rattus norvegicus
2.8.3.13 2.2
-
methylmalonate pH 7.8, 30°C, cosubstrate malonylCoA Rattus norvegicus
2.8.3.13 2.33
-
3-hydroxy-3-methylglutarate pH 7.8, 30°C, cosubstrate methylmalonyl-CoA Rattus norvegicus
2.8.3.13 2.44
-
methylmalonate pH 7.8, 30°C, cosubstrate glutaryl-CoA Rattus norvegicus
2.8.3.13 2.7
-
methylmalonate pH 7.8, 30°C, cosubstrate succinyl-CoA Rattus norvegicus
2.8.3.13 3.05
-
methylmalonate pH 7.8, 30°C, cosubstrate adipyl-CoA Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.3.13 mitochondrion
-
Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.3.13 succinyl-CoA + 3-hydroxy-3-methylglutarate Rattus norvegicus involved in regulation of the tricarboxylic acid cycle rate and ketogenesis succinate + 3-hydroxy-3-methylglutaryl-CoA
-
r

Organism

EC Number Organism UniProt Comment Textmining
2.8.3.13 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.8.3.13
-
Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.3.13 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.3.13 3-hydroxy-3-methylglutaryl-CoA + adipate
-
Rattus norvegicus 3-hydroxy-3-methylglutarate + adipyl-CoA
-
r
2.8.3.13 3-hydroxy-3-methylglutaryl-CoA + glutarate
-
Rattus norvegicus 3-hydroxy-3-methylglutarate + glutaryl-CoA
-
r
2.8.3.13 3-hydroxy-3-methylglutaryl-CoA + malonate
-
Rattus norvegicus 3-hydroxy-3-methylglutarate + malonyl-CoA
-
r
2.8.3.13 3-hydroxy-3-methylglutaryl-CoA + methylmalonate
-
Rattus norvegicus 3-hydroxy-3-methylglutarate + methylmalonyl-CoA
-
r
2.8.3.13 3-hydroxy-3-methylglutaryl-CoA + succinate
-
Rattus norvegicus 3-hydroxy-3-methylglutarate + succinyl-CoA
-
r
2.8.3.13 adipyl-CoA + 3-hydroxy-3-methylglutarate
-
Rattus norvegicus adipate + 3-hydroxy-3-methylglutaryl-CoA
-
r
2.8.3.13 adipyl-CoA + 3-hydroxy-3-methylglutarate adipyl-CoA shows highest apparent affinty, forward reaction at 64%, reverse reaction at 32% the rate of the CoA-transfer between adipyl-CoA and succinate Rattus norvegicus adipate + 3-hydroxy-3-methylglutaryl-CoA
-
r
2.8.3.13 adipyl-CoA + glutarate forward reaction at 82%, reverse reaction at 68% the rate of the CoA-transfer between adipyl-CoA and succinate Rattus norvegicus adipate + glutaryl-CoA
-
r
2.8.3.13 adipyl-CoA + malonate forward reaction at 40%, reverse reaction at 43% the rate of the CoA-transfer between adipyl-CoA and succinate Rattus norvegicus adipate + malonyl-CoA
-
r
2.8.3.13 adipyl-CoA + methylmalonate poor substrate, succinyl-CoA, glutaryl-CoA, malonyl-CoA or 3-hydroxy-3-methylglutaryl-CoA can replace adipyl-CoA Rattus norvegicus adipate + methylmalonyl-CoA
-
r
2.8.3.13 adipyl-CoA + succinate best substrates, reverse reaction at 38% the rate of forward reaction Rattus norvegicus adipate + succinyl-CoA
-
r
2.8.3.13 glutaryl-CoA + 3-hydroxy-3-methylglutarate forward and reverse reaction at 50% the rate of the CoA-transfer between adipyl-CoA and succinate Rattus norvegicus glutarate + 3-hydroxy-3-methylglutaryl-CoA
-
r
2.8.3.13 glutaryl-CoA + adipate
-
Rattus norvegicus glutarate + adipyl-CoA
-
r
2.8.3.13 glutaryl-CoA + malonate forward reaction at 33%, reverse reaction at 41% the rate of the CoA-transfer between adipyl-CoA and succinate Rattus norvegicus glutarate + malonyl-CoA
-
r
2.8.3.13 glutaryl-CoA + methylmalonate
-
Rattus norvegicus glutarate + methylmalonyl-CoA
-
r
2.8.3.13 glutaryl-CoA + succinate
-
Rattus norvegicus glutarate + succinyl-CoA
-
r
2.8.3.13 malonyl-CoA + 3-hydroxy-3-methylglutarate forward reaction at 34%, reverse reaction at 23% the rate of the CoA-transfer between adipyl-CoA and succinate Rattus norvegicus malonate + 3-hydroxy-3-methylglutaryl-CoA
-
r
2.8.3.13 malonyl-CoA + adipate
-
Rattus norvegicus malonate + adipyl-CoA
-
r
2.8.3.13 malonyl-CoA + glutarate
-
Rattus norvegicus malonate + glutaryl-CoA
-
r
2.8.3.13 malonyl-CoA + methylmalonate
-
Rattus norvegicus malonate + methylmalonyl-CoA
-
r
2.8.3.13 malonyl-CoA + succinate
-
Rattus norvegicus malonate + succinyl-CoA
-
r
2.8.3.13 methylmalonyl-CoA + 3-hydroxy-3-methylglutarate
-
Rattus norvegicus methylmalonate + 3-hydroxy-3-methylglutaryl-CoA
-
r
2.8.3.13 methylmalonyl-CoA + adipate
-
Rattus norvegicus methylmalonate + adipyl-CoA
-
r
2.8.3.13 methylmalonyl-CoA + glutarate
-
Rattus norvegicus methylmalonate + glutaryl-CoA
-
r
2.8.3.13 methylmalonyl-CoA + malonate
-
Rattus norvegicus methylmalonate + malonyl-CoA
-
r
2.8.3.13 methylmalonyl-CoA + succinate
-
Rattus norvegicus methylmalonate + succinyl-CoA
-
r
2.8.3.13 succinyl-CoA + 3-hydroxy-3-methylglutarate
-
Rattus norvegicus succinate + 3-hydroxy-3-methylglutaryl-CoA
-
r
2.8.3.13 succinyl-CoA + 3-hydroxy-3-methylglutarate involved in regulation of the tricarboxylic acid cycle rate and ketogenesis Rattus norvegicus succinate + 3-hydroxy-3-methylglutaryl-CoA
-
r
2.8.3.13 succinyl-CoA + adipate
-
Rattus norvegicus succinate + adipyl-CoA
-
r
2.8.3.13 succinyl-CoA + glutarate forward reaction at 58%, reverse reaction at 55% the rate of the CoA-transfer between adipyl-CoA and succinate Rattus norvegicus succinate + glutaryl-CoA
-
r
2.8.3.13 succinyl-CoA + malonate forward reaction at 29%, reverse reaction at 22% the rate of the CoA-transfer between adipyl-CoA and succinate Rattus norvegicus succinate + malonyl-CoA
-
r
2.8.3.13 succinyl-CoA + methylmalonate
-
Rattus norvegicus succinate + methylmalonyl-CoA
-
r

Synonyms

EC Number Synonyms Comment Organism
2.8.3.13 dicarboxyl-CoA:dicarboxylic acid coenzyme A transferase this seems to be a more appropriate name than the recommended or systematic name, due to the substrate specificity as documented Rattus norvegicus