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Literature summary extracted from

  • Ichimori, K.; Fukahori, M.; Nakazawa, H.; Okamoto, K.; Nishino, T.
    Inhibition of xanthine oxidase and xanthine dehydrogenase by nitric oxid (1999), J. Biol. Chem., 274, 7763-7768.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.1.4 NO dose-dependent inhibition of xanthine dehydrogenase and oxidase activity, reaction with an essential sulfur in the molybdenum center, that damages the molybdopterin Bos taurus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.17.1.4 Iron-sulfur-center 2 Fe2-S2-clusters Bos taurus
1.17.1.4 molybdenum-center
-
Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.1.4 xanthine + NAD+ + H2O Bos taurus NAD+-dependent dehydrogenase type D urate + NADH
-
?
1.17.1.4 xanthine + O2 + H2O Bos taurus
-
urate + O2- + 2 H+
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.17.1.4 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.1.4 milk
-
Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.1.4 xanthine + NAD+ + H2O NAD+-dependent dehydrogenase type D Bos taurus urate + NADH
-
?
1.17.1.4 xanthine + O2 + H2O
-
Bos taurus urate + O2- + 2 H+
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.1.4 FAD
-
Bos taurus
1.17.1.4 NAD+
-
Bos taurus