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Literature summary extracted from

  • Hughes, R.K.; Doyle, W.A.; Chovnick, A.; Whittle, J.R.S.; Burke, J.F.; Bray, R.C.
    Use of rosy mutant strains of Drosophila melanogaster to probe the structure and function of xanthine dehydrogenase (1992), Biochem. J., 285, 507-513.
No PubMed abstract available

Application

EC Number Application Comment Organism
1.17.1.4 analysis use of rosy mutant strains to probe structure and function of xanthine dehydrogenase Drosophila melanogaster

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.17.1.4 Fe iron-sulfur groups Drosophila melanogaster
1.17.1.4 Iron-sulfur-center substitutions G42E, E89K, L127F located within the iron-sulfur domain Drosophila melanogaster
1.17.1.4 Mo
-
 Drosophila melanogaster
1.17.1.4 molybdenum-center substitutions G800E, G1011E, G1164R, G1266D, S1275F located within the pterin molybdenum cofactor domain Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.1.4 2-amino-4-hydroxy-pterin + NAD+ + H2O Drosophila melanogaster i.e. pterin isoxanthopterin + NADH
-
 ?
1.17.1.4 xanthine + NAD+ + H2O Drosophila melanogaster
-
 urate + NADH
-
 ?
1.17.1.4 xanthine + O2 + H2O Drosophila melanogaster
-
 urate + O2- + 2 H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.1.4 Drosophila melanogaster
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.1.4 whole body selection of 11 rosy mutant strain, corresponding to single amino acid substitutions for detailed studies on the activities Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.1.4 2-amino-4-hydroxy-pterin + NAD+ + H2O i.e. pterin Drosophila melanogaster isoxanthopterin + NADH
-
 ?
1.17.1.4 2-amino-4-hydroxypterin + NAD+ + H2O i.e. pterin Drosophila melanogaster isoxanthopterin + NADH
-
 ?
1.17.1.4 NADH + electron acceptor + H2O electron acceptors: 2,6-dichlorphenolindophenol or methyl viologen Drosophila melanogaster NAD+ + reduced electron acceptor
-
 ?
1.17.1.4 NADPH + phenazine methosulfate + cytochrome c
-
 Drosophila melanogaster NADP+ + ?
-
 ?
1.17.1.4 xanthine + 2,6-dichlorophenolindophenol + H2O
-
 Drosophila melanogaster urate + ?
-
 ?
1.17.1.4 xanthine + NAD+ + H2O
-
 Drosophila melanogaster urate + NADH
-
 ?
1.17.1.4 xanthine + O2 + H2O
-
 Drosophila melanogaster urate + O2- + 2 H+
-
 ?
1.17.1.4 xanthine + phenazine methosulfate + cytochrome c + H2O
-
 Drosophila melanogaster urate + ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.1.4 FAD substitutions G348E, G353D, S357F located within the flavin/NAD+/NADH-domain Drosophila melanogaster
1.17.1.4 additional information
-
 Drosophila melanogaster
1.17.1.4 NAD+
-
 Drosophila melanogaster