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Literature summary extracted from
- Hepatic bile salt sulfotransferases in the rat: sulfation of 3beta-hydroxy-5-cholenoate during development (1991), J. Ped. Gastroent. Nutri., 12, 260-268.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.8.2.14 | estrogen | isoenzyme BSS I is stimulated by | Rattus norvegicus |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.8.2.14 | 3-ketolithocholate | isoenzyme BSS I completely inhibited, isoenzyme BSS II only 13% | Rattus norvegicus | |
| 2.8.2.14 | Co2+ | isoenzyme BSS II | Rattus norvegicus | |
| 2.8.2.14 | Cu2+ | inhibits both isoenzymes, BSS I and BSS II | Rattus norvegicus | |
| 2.8.2.14 | Zn2+ | isoenzyme BSS II | Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 2.8.2.14 | cytosol | - |
Rattus norvegicus | 5829 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.8.2.14 | Co2+ | isoenzyme BSS I activity enhanced, BSS II activity inhibited | Rattus norvegicus | |
| 2.8.2.14 | Zn2+ | isoenzyme BSS I activity enhanced, BSS II activity inhibited | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.8.2.14 | 3'-phosphoadenylyl sulfate + taurolithocholate | Rattus norvegicus | alternate pathway of bile acid synthesis | adenosine 3',5'-bisphosphate + taurolithocholate sulfate | - |
? | |
| 2.8.2.14 | 3'-phosphoadenylyl sulfate + taurolithocholate | Rattus norvegicus Sprague-Dawley | alternate pathway of bile acid synthesis | adenosine 3',5'-bisphosphate + taurolithocholate sulfate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.8.2.14 | Rattus norvegicus | - |
rat | - |
| 2.8.2.14 | Rattus norvegicus | - |
Sprague-Dawley | - |
| 2.8.2.14 | Rattus norvegicus Sprague-Dawley | - |
Sprague-Dawley | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 2.8.2.14 | partially, isoenzyme BSS II | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 2.8.2.14 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.8.2.14 | 3'-phosphoadenylyl sulfate + taurolithocholate | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + taurolithocholate sulfate | - |
? | |
| 2.8.2.14 | 3'-phosphoadenylyl sulfate + taurolithocholate | alternate pathway of bile acid synthesis | Rattus norvegicus | adenosine 3',5'-bisphosphate + taurolithocholate sulfate | - |
? | |
| 2.8.2.14 | 3'-phosphoadenylyl sulfate + taurolithocholate | - |
Rattus norvegicus Sprague-Dawley | adenosine 3',5'-bisphosphate + taurolithocholate sulfate | - |
? | |
| 2.8.2.14 | 3'-phosphoadenylyl sulfate + taurolithocholate | alternate pathway of bile acid synthesis | Rattus norvegicus Sprague-Dawley | adenosine 3',5'-bisphosphate + taurolithocholate sulfate | - |
? | |
| 2.8.2.14 | 3'-phosphoadenylyl-sulfate + 3beta-hydroxy 5-cholenoate | isoenzyme BSS I | Rattus norvegicus | adenosine 3',5'-bisphosphate + 3beta-hydroxy 5-cholenoate monosulfate | - |
? | |
| 2.8.2.14 | 3'-phosphoadenylyl-sulfate + 3beta-hydroxy 5-cholenoate | isoenzyme BSS I | Rattus norvegicus Sprague-Dawley | adenosine 3',5'-bisphosphate + 3beta-hydroxy 5-cholenoate monosulfate | - |
? | |
| 2.8.2.14 | 3'-phosphoadenylyl-sulfate + chenodeoxycholate | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate | - |
? | |
| 2.8.2.14 | 3'-phosphoadenylyl-sulfate + cholic acid | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + cholic acid sulfate | - |
? | |
| 2.8.2.14 | 3'-phosphoadenylyl-sulfate + deoxycholate | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + deoxycholate 12-sulfate | - |
? | |
| 2.8.2.14 | 3'-phosphoadenylyl-sulfate + glycolithocholate | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate | - |
? | |
| 2.8.2.14 | 3'-phosphoadenylyl-sulfate + glycolithocholate | - |
Rattus norvegicus Sprague-Dawley | adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate | - |
? | |
| 2.8.2.14 | 3'-phosphoadenylyl-sulfate + lithocholate | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + lithocholate 3-sulfate | - |
? | |
| 2.8.2.14 | 3'-phosphoadenylyl-sulfate + lithocholate | - |
Rattus norvegicus Sprague-Dawley | adenosine 3',5'-bisphosphate + lithocholate 3-sulfate | - |
? | |
| 2.8.2.14 | 3'-phosphoadenylyl-sulfate + ursodeoxycholate | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + ursodeoxycholate sulfate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 2.8.2.14 | 3beta-hydroxy-5-cholenoate sulfotransferase | - |
Rattus norvegicus |
| 2.8.2.14 | BSS I | predominant isoenzyme | Rattus norvegicus |
| 2.8.2.14 | BSS II | - |
Rattus norvegicus |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 2.8.2.14 | 0.0033 | - |
3-ketolithocholate | pH 6.5, 37°C | Rattus norvegicus | |
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