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Literature summary extracted from

  • Grobe, K.; Ledin, J.; Ringvall, M.; Holmborn, K.; Forsberg, E.; Esko, J.D.; Kjellen, L.
    Heparan sulfate and development: differential roles of the N-acetylglucosamine N-deacetylase/N-sulfotransferase isozymes (2002), Biochim. Biophys. Acta, 1573, 209-215.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.8 overexpression of isozymes NDST1 and NDST2 in human kidney cells 293 Mus musculus
2.8.2.8 stable functional overexpression in human kidney cell line 293, 2.5fold increase in N-sulfation and 8fold increase of N-deacetylation of glucosaminyl residues of human heparan sulfate in transfected cells Mus musculus

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.8.2.8 structure Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.8.2.8 additional information knockout mice construction: mice lacking NDST2 show a phenotype restricted to connective tissue-type mast cells, while NDST1 deficiency is lethal, double-knockouts show early embryonic lethality, in utero effect of NDST3 deficiency Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.8 Golgi apparatus localized to the medial- or trans-Golgi network Drosophila melanogaster 5794
-
2.8.2.8 Golgi apparatus localized to the medial- or trans-Golgi network Mus musculus 5794
-
2.8.2.8 Golgi apparatus localized to the medial- or trans-Golgi network Caenorhabditis elegans 5794
-
2.8.2.8 additional information type II membrane proteins Drosophila melanogaster
-
-
2.8.2.8 additional information type II membrane proteins Mus musculus
-
-
2.8.2.8 additional information type II membrane proteins Caenorhabditis elegans
-
-
2.8.2.8 additional information type II membrane proteins vertebrata
-
-
2.8.2.8 additional information type II membrane proteins Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.8 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine Drosophila melanogaster bifunctional enzyme initiates heparin and heparan sulfate biosynthesis adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
 ?
2.8.2.8 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine Mus musculus bifunctional enzyme initiates heparin and heparan sulfate biosynthesis adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
 ?
2.8.2.8 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine Caenorhabditis elegans bifunctional enzyme initiates heparin and heparan sulfate biosynthesis adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
 ?
2.8.2.8 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine Mus musculus isozyme regulation, developmental importance in different tissues adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
 ?
2.8.2.8 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine vertebrata isozyme regulation, developmental importance in different tissues adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.8 Caenorhabditis elegans
-
 possesses only 1 isozyme
-
2.8.2.8 Drosophila melanogaster
-
 possesses only 1 isozyme
-
2.8.2.8 Homo sapiens
-
-
-
2.8.2.8 Homo sapiens O95803
-
-
2.8.2.8 Homo sapiens Q9H3R1 isozyme NDST4
-
2.8.2.8 Mus musculus
-
 isozymes NDST1-4
-
2.8.2.8 Mus musculus Q9EQW8 isozyme NDST4
-
2.8.2.8 vertebrata
-
 isozymes NDST1-4
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.8 brain low activity Mus musculus
-
2.8.2.8 brain low activity Homo sapiens
-
2.8.2.8 brain adult Homo sapiens
-
2.8.2.8 brain adult Mus musculus
-
2.8.2.8 embryo isozymes NDST3 and NDST4 are predominantly expressed during embryonic development vertebrata
-
2.8.2.8 heart
-
 Homo sapiens
-
2.8.2.8 additional information
-
 Mus musculus
-
2.8.2.8 additional information NDST1 and NDST2 mRNA are widespread in the body, but the isozymes are not expressed in many tissues on protein level Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.8 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
-
 Drosophila melanogaster adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
 ?
2.8.2.8 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
-
 Mus musculus adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
 ?
2.8.2.8 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
-
 Homo sapiens adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
 ?
2.8.2.8 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
-
 Caenorhabditis elegans adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
 ?
2.8.2.8 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
-
 vertebrata adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
 ?
2.8.2.8 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine bifunctional enzyme initiates heparin and heparan sulfate biosynthesis Drosophila melanogaster adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
 ?
2.8.2.8 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine bifunctional enzyme initiates heparin and heparan sulfate biosynthesis Mus musculus adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
 ?
2.8.2.8 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine bifunctional enzyme initiates heparin and heparan sulfate biosynthesis Caenorhabditis elegans adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
 ?
2.8.2.8 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine isozyme regulation, developmental importance in different tissues Mus musculus adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
 ?
2.8.2.8 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine isozyme regulation, developmental importance in different tissues vertebrata adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.8 N-acetylglucosamine N-deacetylase/N-sulfotransferase
-
 Drosophila melanogaster
2.8.2.8 N-acetylglucosamine N-deacetylase/N-sulfotransferase
-
 Mus musculus
2.8.2.8 N-acetylglucosamine N-deacetylase/N-sulfotransferase
-
 Caenorhabditis elegans
2.8.2.8 NDST
-
 Drosophila melanogaster
2.8.2.8 NDST
-
 Mus musculus
2.8.2.8 NDST
-
 Homo sapiens
2.8.2.8 NDST
-
 Caenorhabditis elegans
2.8.2.8 NDST
-
 vertebrata