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Literature summary extracted from

  • Klees, A.G.; Buckel, W.
    Synthesis and properties of (R)-2-hydroxyglutaryl-1-CoA. (R)-2-hydroxyglutaryl-5-CoA, an erroneous product of glutaconate CoA-transferase (1991), Biol. Chem. Hoppe-Seyler, 372, 319-324.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.3.12 0.035
-
 (R)-2-hydroxyglutaryl-1-CoA pH 7, 37°C, cosubstrate acetate Acidaminococcus fermentans

Organism

EC Number Organism UniProt Comment Textmining
2.8.3.12 Acidaminococcus fermentans
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.3.12 acetyl-CoA + (E)-glutaconate
-
 Acidaminococcus fermentans acetate + glutaconyl-1-CoA only 1-isomer is formed ?
2.8.3.12 acetyl-CoA + (R)-2-hydroxyglutarate
-
 Acidaminococcus fermentans acetate + (R)-2-hydroxyglutaryl-1-CoA in vitro formation of both isomers: (R)-2-hydroxyglutaryl-1-CoA and (R)-2-hydroxyglutaryl-5-CoA, the 1-isomer is kinetically favoured, the 5-isomer is thermodynamically favoured r
2.8.3.12 acetyl-CoA + (R)-2-hydroxyglutarate
-
 Acidaminococcus fermentans acetate + (R)-2-hydroxyglutaryl-1-CoA product in vivo, 5-isomer only occurs in vitro, (R)-2-hydroxyglutaryl-1-CoA is an excellent substrate in the reverse reaction r
2.8.3.12 glutaconyl-CoA + (R)-2-hydroxyglutarate
-
 Acidaminococcus fermentans glutaconate + (R)-2-hydroxyglutaryl-CoA formation of the 5-isomer, not of the 1-isomer ?
2.8.3.12 additional information no substrate: lactone-CoA Acidaminococcus fermentans ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.8.3.12 37
-
 assay at Acidaminococcus fermentans

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.8.3.12 7
-
 assay at Acidaminococcus fermentans