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Literature summary extracted from

  • Knauer, T.E.
    Factors affecting the activity and stability of the palmitoyl-coenzyme A hydrolase of rat brain (1979), Biochem. J., 179, 515-523.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.2.2 5,5'-dithiobis(2-nitrobenzoate)
-
 Rattus norvegicus
3.1.2.2 Hg2+
-
 Rattus norvegicus
3.1.2.2 Mg2+
-
 Rattus norvegicus
3.1.2.2 p-hydroxymercuribenzoate
-
 Rattus norvegicus
3.1.2.20 5,5'-dithiobis(2-nitrobenzoate)
-
 Rattus norvegicus
3.1.2.20 Hg2+
-
 Rattus norvegicus
3.1.2.20 Mg2+
-
 Rattus norvegicus
3.1.2.20 p-hydroxymercuribenzoate
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.2.2 mitochondrion
-
 Rattus norvegicus 5739
-
3.1.2.20 mitochondrion
-
 Rattus norvegicus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.2.2 70000
-
 gel filtration Rattus norvegicus
3.1.2.2 130000
-
 gel filtration, glycerol is included in the eluting buffer Rattus norvegicus
3.1.2.20 70000
-
 gel filtration Rattus norvegicus
3.1.2.20 130000
-
 gel filtration, glycerol is included in the eluting buffer Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.2.2 palmitoyl-CoA + H2O Rattus norvegicus
-
 CoA + palmitate
-
 ?
3.1.2.20 palmitoyl-CoA + H2O Rattus norvegicus
-
 CoA + palmitate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.2 Rattus norvegicus
-
-
-
3.1.2.20 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.2.2 brain
-
 Rattus norvegicus
-
3.1.2.20 brain
-
 Rattus norvegicus
-

Storage Stability

EC Number Storage Stability Organism
3.1.2.2 -50°C over 2 months Rattus norvegicus
3.1.2.2 0°C, unstable Rattus norvegicus
3.1.2.20 -50°C over 2 months Rattus norvegicus
3.1.2.20 0°C, unstable Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.2 acyl-CoA + H2O long-chain fatty-acyl-CoA Rattus norvegicus CoA + a carboxylate
-
 ir
3.1.2.2 hexadecanoyl-CoA + H2O i.e. palmitoyl-CoA Rattus norvegicus CoA + hexadecanoate
-
 ir
3.1.2.2 palmitoyl-CoA + H2O
-
 Rattus norvegicus CoA + palmitate
-
 ?
3.1.2.20 acyl-CoA + H2O long-chain fatty-acyl-CoA Rattus norvegicus CoA + a carboxylate
-
 ir
3.1.2.20 hexadecanoyl-CoA + H2O i.e. palmitoyl-CoA Rattus norvegicus CoA + hexadecanoate
-
 ir
3.1.2.20 palmitoyl-CoA + H2O
-
 Rattus norvegicus CoA + palmitate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.2.2 7.5
-
-
 Rattus norvegicus
3.1.2.20 7.5
-
-
 Rattus norvegicus