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Literature summary extracted from

  • Poupon, V.; Begue, B.; Gagnon, J.; Dautry-Varsat, A.; Cerf-Bensussan, N.; Benmerah, A.
    Molecular cloning and characterization of MT-ACT48, a novel mitochondrial acyl-CoA thioesterase (1999), J. Biol. Chem., 274, 19188-19194.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.2.2 from murine EST library, DNA and amino acid sequence determination and analysis, transient expression in HeLa cells, expression as inactive GST-fusion protein in bacteria Mus musculus
3.1.2.20 from murine EST library, DNA and amino acid sequence determination and analysis, transient expression in HeLa cells, expression as inactive GST-fusion protein in bacteria Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.2.2 cytosol
-
 Homo sapiens 5829
-
3.1.2.2 cytosol
-
 Rattus norvegicus 5829
-
3.1.2.2 cytosol
-
 Oryctolagus cuniculus 5829
-
3.1.2.2 endoplasmic reticulum
-
 Rattus norvegicus 5783
-
3.1.2.2 endoplasmic reticulum
-
 Arabidopsis thaliana 5783
-
3.1.2.2 mitochondrion
-
 Homo sapiens 5739
-
3.1.2.2 mitochondrion
-
 Rattus norvegicus 5739
-
3.1.2.2 mitochondrion
-
 Oryctolagus cuniculus 5739
-
3.1.2.2 mitochondrion
-
 Mus musculus 5739
-
3.1.2.20 cytosol
-
 Homo sapiens 5829
-
3.1.2.20 cytosol
-
 Rattus norvegicus 5829
-
3.1.2.20 cytosol
-
 Oryctolagus cuniculus 5829
-
3.1.2.20 endoplasmic reticulum
-
 Rattus norvegicus 5783
-
3.1.2.20 endoplasmic reticulum
-
 Arabidopsis thaliana 5783
-
3.1.2.20 mitochondrion
-
 Homo sapiens 5739
-
3.1.2.20 mitochondrion
-
 Rattus norvegicus 5739
-
3.1.2.20 mitochondrion
-
 Oryctolagus cuniculus 5739
-
3.1.2.20 mitochondrion
-
 Mus musculus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.2.2 48000
-
 x * 48000, SDS-PAGE Mus musculus
3.1.2.20 48000
-
 x * 48000, SDS-PAGE Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.2 Arabidopsis thaliana
-
-
-
3.1.2.2 Bacillus subtilis
-
-
-
3.1.2.2 Caenorhabditis elegans
-
-
-
3.1.2.2 Drosophila melanogaster
-
-
-
3.1.2.2 Escherichia coli
-
-
-
3.1.2.2 Haemophilus influenzae
-
-
-
3.1.2.2 Helicobacter pylori
-
-
-
3.1.2.2 Homo sapiens
-
-
-
3.1.2.2 Mus musculus Q9R0X4 mitochondrial p48 enzyme MT-ACT48-1, isozyme 1
-
3.1.2.2 Mus musculus Q9R0X4 mitochondrial p48 enzyme MT-ACT48-2, isozyme 2
-
3.1.2.2 Oryctolagus cuniculus
-
-
-
3.1.2.2 Rattus norvegicus
-
-
-
3.1.2.20 Arabidopsis thaliana
-
-
-
3.1.2.20 Bacillus subtilis
-
-
-
3.1.2.20 Caenorhabditis elegans
-
-
-
3.1.2.20 Drosophila melanogaster
-
-
-
3.1.2.20 Escherichia coli
-
-
-
3.1.2.20 Haemophilus influenzae
-
-
-
3.1.2.20 Helicobacter pylori
-
-
-
3.1.2.20 Homo sapiens
-
-
-
3.1.2.20 Mus musculus Q9R0X4 mitochondrial p48 enzyme MT-ACT48-1, isozyme 1
-
3.1.2.20 Mus musculus Q9R0X4 mitochondrial p48 enzyme MT-ACT48-2, isozyme 2
-
3.1.2.20 Oryctolagus cuniculus
-
-
-
3.1.2.20 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.2.2 no glycoprotein p48 is not N-glycosylated and does not enter the secretion pathway Mus musculus
3.1.2.20 no glycoprotein p48 is not N-glycosylated and does not enter the secretion pathway Mus musculus

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.2.2 recombinant from HeLa cells Mus musculus
3.1.2.20 recombinant from HeLa cells Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.2.2 aorta
-
 Homo sapiens
-
3.1.2.2 brain
-
 Homo sapiens
-
3.1.2.2 brain
-
 Rattus norvegicus
-
3.1.2.2 brain
-
 Oryctolagus cuniculus
-
3.1.2.2 liver
-
 Homo sapiens
-
3.1.2.2 liver
-
 Rattus norvegicus
-
3.1.2.2 additional information
-
 Rattus norvegicus
-
3.1.2.2 additional information ubiquitous expression Mus musculus
-
3.1.2.2 ovary
-
 Homo sapiens
-
3.1.2.2 placenta
-
 Homo sapiens
-
3.1.2.2 spleen
-
 Homo sapiens
-
3.1.2.2 spleen
-
 Rattus norvegicus
-
3.1.2.2 testis
-
 Homo sapiens
-
3.1.2.2 testis
-
 Rattus norvegicus
-
3.1.2.2 thyroid gland
-
 Homo sapiens
-
3.1.2.20 aorta
-
 Homo sapiens
-
3.1.2.20 brain
-
 Homo sapiens
-
3.1.2.20 brain
-
 Rattus norvegicus
-
3.1.2.20 brain
-
 Oryctolagus cuniculus
-
3.1.2.20 liver
-
 Homo sapiens
-
3.1.2.20 liver
-
 Rattus norvegicus
-
3.1.2.20 additional information
-
 Rattus norvegicus
-
3.1.2.20 additional information ubiquitous expression Mus musculus
-
3.1.2.20 ovary
-
 Homo sapiens
-
3.1.2.20 placenta
-
 Homo sapiens
-
3.1.2.20 spleen
-
 Homo sapiens
-
3.1.2.20 spleen
-
 Rattus norvegicus
-
3.1.2.20 testis
-
 Homo sapiens
-
3.1.2.20 testis
-
 Rattus norvegicus
-
3.1.2.20 thyroid gland
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.2 acyl-CoA + H2O
-
 Homo sapiens CoA + a carboxylate
-
 ?
3.1.2.2 acyl-CoA + H2O
-
 Oryctolagus cuniculus CoA + a carboxylate
-
 ?
3.1.2.2 acyl-CoA + H2O
-
 Mus musculus CoA + a carboxylate
-
 ?
3.1.2.2 acyl-CoA + H2O long-chain fatty-acyl-CoA Escherichia coli CoA + a carboxylate
-
 ?
3.1.2.2 acyl-CoA + H2O long-chain fatty-acyl-CoA Rattus norvegicus CoA + a carboxylate
-
 ?
3.1.2.2 decanoyl-CoA + H2O
-
 Escherichia coli CoA + decanoate
-
 ?
3.1.2.2 decanoyl-CoA + H2O
-
 Rattus norvegicus CoA + decanoate
-
 ?
3.1.2.2 decanoyl-CoA + H2O
-
 Mus musculus CoA + decanoate
-
 ?
3.1.2.2 hexanoyl-CoA + H2O
-
 Escherichia coli CoA + hexanoate
-
 ?
3.1.2.2 hexanoyl-CoA + H2O
-
 Mus musculus CoA + hexanoate
-
 ?
3.1.2.2 octadecanoyl-CoA + H2O
-
 Escherichia coli CoA + octadecanoate
-
 ?
3.1.2.2 octadecanoyl-CoA + H2O
-
 Rattus norvegicus CoA + octadecanoate
-
 ?
3.1.2.2 octadecanoyl-CoA + H2O
-
 Mus musculus CoA + octadecanoate
-
 ?
3.1.2.2 tetradecanoyl-CoA + H2O
-
 Mus musculus CoA + tetradecanoate
-
 ?
3.1.2.2 tetradecanoyl-CoA + H2O i.e. myristoyl-CoA Escherichia coli CoA + tetradecanoate
-
 ?
3.1.2.2 tetradecanoyl-CoA + H2O i.e. myristoyl-CoA Rattus norvegicus CoA + tetradecanoate
-
 ?
3.1.2.20 acyl-CoA + H2O
-
 Homo sapiens CoA + a carboxylate
-
 ?
3.1.2.20 acyl-CoA + H2O
-
 Oryctolagus cuniculus CoA + a carboxylate
-
 ?
3.1.2.20 acyl-CoA + H2O
-
 Mus musculus CoA + a carboxylate
-
 ?
3.1.2.20 acyl-CoA + H2O long-chain fatty-acyl-CoA Escherichia coli CoA + a carboxylate
-
 ?
3.1.2.20 acyl-CoA + H2O long-chain fatty-acyl-CoA Rattus norvegicus CoA + a carboxylate
-
 ?
3.1.2.20 decanoyl-CoA + H2O
-
 Escherichia coli CoA + decanoate
-
 ?
3.1.2.20 decanoyl-CoA + H2O
-
 Rattus norvegicus CoA + decanoate
-
 ?
3.1.2.20 decanoyl-CoA + H2O
-
 Mus musculus CoA + decanoate
-
 ?
3.1.2.20 hexanoyl-CoA + H2O
-
 Escherichia coli CoA + hexanoate
-
 ?
3.1.2.20 hexanoyl-CoA + H2O
-
 Mus musculus CoA + hexanoate
-
 ?
3.1.2.20 octadecanoyl-CoA + H2O
-
 Escherichia coli CoA + octadecanoate
-
 ?
3.1.2.20 octadecanoyl-CoA + H2O
-
 Rattus norvegicus CoA + octadecanoate
-
 ?
3.1.2.20 octadecanoyl-CoA + H2O
-
 Mus musculus CoA + octadecanoate
-
 ?
3.1.2.20 tetradecanoyl-CoA + H2O
-
 Mus musculus CoA + tetradecanoate
-
 ?
3.1.2.20 tetradecanoyl-CoA + H2O i.e. myristoyl-CoA Escherichia coli CoA + tetradecanoate
-
 ?
3.1.2.20 tetradecanoyl-CoA + H2O i.e. myristoyl-CoA Rattus norvegicus CoA + tetradecanoate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.2.2 ?
-
 Homo sapiens
3.1.2.2 ?
-
 Rattus norvegicus
3.1.2.2 ? x * 48000, SDS-PAGE Mus musculus
3.1.2.20 ?
-
 Homo sapiens
3.1.2.20 ?
-
 Rattus norvegicus
3.1.2.20 ? x * 48000, SDS-PAGE Mus musculus

Synonyms

EC Number Synonyms Comment Organism
3.1.2.2 MT-ACT48 2 isozymes Mus musculus
3.1.2.20 MT-ACT48 2 isozymes Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.2.2 22
-
 assay at Mus musculus
3.1.2.20 22
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.2.2 8
-
-
 Rattus norvegicus
3.1.2.2 8
-
 assay at Oryctolagus cuniculus
3.1.2.2 8
-
 assay at Mus musculus
3.1.2.20 8
-
-
 Rattus norvegicus
3.1.2.20 8
-
 assay at Oryctolagus cuniculus
3.1.2.20 8
-
 assay at Mus musculus