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Literature summary extracted from

  • Jones, J.M.; Nau, K.; Geraghty, M.T.; Erdmann, R.; Gould, S.J.
    Identification of peroxisomal acyl-CoA thioesterases in yeast and humans (1999), J. Biol. Chem., 274, 9216-9223.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.2.2 oleate induces enzyme expression in peroxisomes Saccharomyces cerevisiae
3.1.2.20 oleate induces enzyme expression in peroxisomes Saccharomyces cerevisiae

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.2.2 DNA sequence determination and analysis, subcloning in Escherichia coli, expression fused to maltose-binding-protein in Escherichia coli strain DH10B Homo sapiens
3.1.2.2 gene YJR019C, DNA sequence determination and analysis, subcloning in Escherichia coli, expression fused to maltose-binding-protein in Escherichia coli strain DH10B Saccharomyces cerevisiae
3.1.2.20 DNA sequence determination and analysis, subcloning in Escherichia coli, expression fused to maltose-binding-protein in Escherichia coli strain DH10B Homo sapiens
3.1.2.20 gene YJR019C, DNA sequence determination and analysis, subcloning in Escherichia coli, expression fused to maltose-binding-protein in Escherichia coli strain DH10B Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.2.2 peroxisome
-
 Homo sapiens 5777
-
3.1.2.2 peroxisome
-
 Saccharomyces cerevisiae 5777
-
3.1.2.20 peroxisome
-
 Homo sapiens 5777
-
3.1.2.20 peroxisome
-
 Saccharomyces cerevisiae 5777
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.2.2 36000
-
 x * 36000, SDS-PAGE Homo sapiens
3.1.2.20 36000
-
 x * 36000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.2.2 acyl-CoA + H2O Saccharomyces cerevisiae involved in fatty acid metabolism CoA + a carboxylate
-
 ?
3.1.2.20 acyl-CoA + H2O Saccharomyces cerevisiae involved in fatty acid metabolism CoA + a carboxylate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.2 Homo sapiens O14734 should be renamed as PTE I
-
3.1.2.2 Homo sapiens O14734 hTE
-
3.1.2.2 Saccharomyces cerevisiae P41903 should be renamed as PTE I
-
3.1.2.2 Saccharomyces cerevisiae P41903 gene YJR019C, expression is inducible by oleate
-
3.1.2.20 Homo sapiens O14734 should be renamed as PTE I
-
3.1.2.20 Homo sapiens O14734 hTE
-
3.1.2.20 Saccharomyces cerevisiae P41903 should be renamed as PTE I
-
3.1.2.20 Saccharomyces cerevisiae P41903 gene YJR019C, expression is inducible by oleate
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.2 acyl-CoA + H2O involved in fatty acid metabolism Saccharomyces cerevisiae CoA + a carboxylate
-
 ?
3.1.2.2 decanoyl-CoA + H2O
-
 Homo sapiens CoA + decanoate
-
 ?
3.1.2.2 decanoyl-CoA + H2O
-
 Saccharomyces cerevisiae CoA + decanoate
-
 ?
3.1.2.20 acyl-CoA + H2O involved in fatty acid metabolism Saccharomyces cerevisiae CoA + a carboxylate
-
 ?
3.1.2.20 decanoyl-CoA + H2O
-
 Homo sapiens CoA + decanoate
-
 ?
3.1.2.20 decanoyl-CoA + H2O
-
 Saccharomyces cerevisiae CoA + decanoate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.2.2 ? x * 36000, SDS-PAGE Homo sapiens
3.1.2.20 ? x * 36000, SDS-PAGE Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.2.2 30
-
 assay at Saccharomyces cerevisiae
3.1.2.2 37
-
 assay at Homo sapiens
3.1.2.20 30
-
 assay at Saccharomyces cerevisiae
3.1.2.20 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.2.2 8
-
 assay at Homo sapiens
3.1.2.2 8
-
 assay at Saccharomyces cerevisiae
3.1.2.20 8
-
 assay at Homo sapiens
3.1.2.20 8
-
 assay at Saccharomyces cerevisiae