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Literature summary extracted from

  • Bergstrom, J.D.; Edmond, J.
    Rat liver acetoacetyl-CoA synthetase (1985), Methods Enzymol., 110, 3-9.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.2.1.16 Tris stimulates Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.16 cytosol
-
 Rattus norvegicus 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.2.1.16 K+ monovalent cation required Rattus norvegicus
6.2.1.16 Mg2+
-
 Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.2.1.16 100000
-
 gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.16 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.2.1.16
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.16 adipose tissue
-
 Rattus norvegicus
-
6.2.1.16 adrenal gland
-
 Rattus norvegicus
-
6.2.1.16 liver diurnal variation of activity with the peak in the middle of the dark cycle. Activity level is higher in femals than in males Rattus norvegicus
-
6.2.1.16 mammary gland lactating Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.16 ATP + acetate + CoA 45% of the activity relative to acetoacetate Rattus norvegicus AMP + diphosphate + acetyl-CoA
-
 ?
6.2.1.16 ATP + acetoacetate + CoA no activity with GTP and CTP Rattus norvegicus AMP + diphosphate + acetoacetyl-CoA
-
 ?
6.2.1.16 ATP + L-3-hydroxybutanoate + CoA 20% of the activity relative to acetoacetate Rattus norvegicus AMP + diphosphate + L-3-hydroxybutyryl-CoA
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.2.1.16 7
-
 phosphate buffer Rattus norvegicus
6.2.1.16 7.5
-
 Hepes buffer Rattus norvegicus