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Literature summary extracted from

  • Mancia, F.; Smith, G.A.; Evans, P.R.
    Crystal structure of substrate complexes of methylmalonyl-CoA mutase (1999), Biochemistry, 38, 7999-8005.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.4.99.2 expression in Escherichia coli Propionibacterium freudenreichii subsp. shermanii

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
5.4.99.2 vapour diffusion at 23°C, in the presence of succinyl-CoA, 3-carboxylpropyl-CoA or (2R)-carboxylpropyl-CoA Propionibacterium freudenreichii subsp. shermanii

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.4.99.2 (2R)-carboxylpropyl-CoA
-
 Propionibacterium freudenreichii subsp. shermanii
5.4.99.2 3-carboxylpropyl-CoA
-
 Propionibacterium freudenreichii subsp. shermanii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.4.99.2 (R)-2-methylmalonyl-CoA Propionibacterium freudenreichii subsp. shermanii
-
 succinyl-CoA
-
 r

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.2 Propionibacterium freudenreichii subsp. shermanii
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.4.99.2
-
 Propionibacterium freudenreichii subsp. shermanii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.99.2 (R)-2-methylmalonyl-CoA
-
 Propionibacterium freudenreichii subsp. shermanii succinyl-CoA
-
 r

Synonyms

EC Number Synonyms Comment Organism
5.4.99.2 methylmalonyl-CoA mutase
-
 Propionibacterium freudenreichii subsp. shermanii

Cofactor

EC Number Cofactor Comment Organism Structure
5.4.99.2 adenosylcobalamin
-
 Propionibacterium freudenreichii subsp. shermanii