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Literature summary extracted from

  • Wlodawer, A.; Li, M.; Gustchina, A.; Dauter, Z.; Uchida, K.; Oyama, H.; Goldfarb, N.E.; Dunn, B.M.; Oda, K.
    Inhibitor complexes of the Pseudomonas serine-carboxyl proteinase (2001), Biochemistry, 40, 15602-15611.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.4.21.100 crystal structure complexed with a number of inhibitors (tyrostatin, pseudo-tyrostatin, acetyl-Ile-Pro-Phe, acetyl-Ile-Ala-Phe, iodotyrostatin, pseudotyrostatin and chymostatin), have been solved and refined at high-level to atomic-level resolution Pseudomonas sp.

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.100 acetyl-Ile-Ala-Phe
-
 Pseudomonas sp.
3.4.21.100 acetyl-Ile-Pro-Phe
-
 Pseudomonas sp.
3.4.21.100 chymostatin
-
 Pseudomonas sp.
3.4.21.100 iodotyrostatin
-
 Pseudomonas sp.
3.4.21.100 pseudo-iodotyrostatin
-
 Pseudomonas sp.
3.4.21.100 pseudo-tyrostatin
-
 Pseudomonas sp.
3.4.21.100 Tyrostatin
-
 Pseudomonas sp.

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.21.100 Ca2+ necessary for the activity of the enzyme Pseudomonas sp.

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.100 Pseudomonas sp. P42790
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.100
-
 Pseudomonas sp.

Synonyms

EC Number Synonyms Comment Organism
3.4.21.100 PSCP
-
 Pseudomonas sp.

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.21.100 0.000006
-
 Tyrostatin
-
 Pseudomonas sp.
3.4.21.100 0.000014
-
 pseudo-iodotyrostatin
-
 Pseudomonas sp.
3.4.21.100 0.000032
-
 iodotyrostatin
-
 Pseudomonas sp.
3.4.21.100 0.000045
-
 chymostatin
-
 Pseudomonas sp.
3.4.21.100 0.000056
-
 pseudo-tyrostatin
-
 Pseudomonas sp.
3.4.21.100 0.000415
-
 acetyl-Ile-Pro-Phe
-
 Pseudomonas sp.
3.4.21.100 0.0006
-
 acetyl-Ile-Ala-Phe
-
 Pseudomonas sp.