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Literature summary extracted from

  • Schwarz, G.; Brandenburg, J.; Reich, M.; Burster T.; Driessen, C.; Kalbacher, H.
    Characterization of legumain (2002), Biol. Chem., 383, 1813-1816.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.34 iodoacetamide
-
 Sus scrofa
3.4.22.34 additional information no inhibition by E-64 and EDTA Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.34 endosome
-
 Sus scrofa 5768
-
3.4.22.34 lysosome
-
 Sus scrofa 5764
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.34 protein + H2O Sus scrofa enzyme is critically involved in the lysosomal processing of bacterial antigens for MHC class II presentation peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.34 Sus scrofa
-
 purified enzyme
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.34 B-lymphocyte cell line WT51 cell, EBV-transformed Sus scrofa
-
3.4.22.34 culture condition:antigen-presenting cell different types Sus scrofa
-
3.4.22.34 dendritic cell resting and maturing Sus scrofa
-
3.4.22.34 kidney
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.34 benzyloxycarbonyl-Ala-Glu-Asn-Xaa-Ala-Glu-Lys-NH2 + H2O substrate specificity at S1 position, overview Sus scrofa benzyloxycarbonyl-Ala-Glu-Asn + Xaa-Ala-Glu-Lys-NH2
-
 ?
3.4.22.34 benzyloxycarbonyl-Val-Ala-Asn-4-methylcoumarin-7-amide + H2O fluorogenic substrate Sus scrofa benzyloxycarbonyl-Val-Ala-Asn + 7-amino-4-methylcoumarin
-
 ?
3.4.22.34 myelin basic protein MBP + H2O cleavage sites at positions 84-85 and 92-93, multiple-sclerosis-associated autoantigen, digestion, destruction of the immunodominant epitope 83-99 Sus scrofa 5 fragments product determination ?
3.4.22.34 protein + H2O enzyme is critically involved in the lysosomal processing of bacterial antigens for MHC class II presentation Sus scrofa peptides
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.34 AEP
-
 Sus scrofa
3.4.22.34 Asparaginyl endopeptidase
-
 Sus scrofa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.22.34 37
-
 assay at Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.22.34 5.8
-
 assay at Sus scrofa