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Literature summary extracted from

  • Viergutz, S.; Poppe, L.; Tomin, A.; Retey, J.
    Mechanistic investigation of phenylalanine ammonia lyase by using N-methylated phenylalanines (2003), Helv. Chim. Acta, 86, 3601-3612.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.3.1.24 N,N-dimethyl-4-nitro-L-phenylalanine
-
 Petroselinum crispum
4.3.1.24 N-methyl-4-nitro-L-phenylalanine
-
 Petroselinum crispum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.3.1.24 2.6
-
 NH3 pH 10.0 Petroselinum crispum
4.3.1.24 4.4
-
 NH3 pH 8.8 Petroselinum crispum
4.3.1.24 6.6
-
 N-methyl-L-phenylalanine
-
 Petroselinum crispum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.3.1.24 L-phenylalanine Petroselinum crispum
-
 (E)-cinnamate + NH3
-
 r

Organism

EC Number Organism UniProt Comment Textmining
4.3.1.24 Petroselinum crispum
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.3.1.24 L-phenylalanine
-
 Petroselinum crispum (E)-cinnamate + NH3
-
 ?
4.3.1.24 L-phenylalanine
-
 Petroselinum crispum (E)-cinnamate + NH3
-
 r
4.3.1.24 N-methyl-L-phenylalanine
-
 Petroselinum crispum trans-cinnamate + methylamine
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.3.1.24 0.22
-
 N-methyl-L-phenylalanine
-
 Petroselinum crispum

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.3.1.24 0.000008
-
 N,N-dimethyl-4-nitro-L-phenylalanine
-
 Petroselinum crispum
4.3.1.24 0.00013
-
 N-methyl-4-nitro-L-phenylalanine
-
 Petroselinum crispum