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Literature summary extracted from

  • Korotkova, N.; Lidstrom, M.E.
    MeaB is a component of the methylmalonyl-CoA mutase complex required for protection of the enzyme from inactivation (2004), J. Biol. Chem., 279, 13652-13658.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.4.99.2 expression in Escherichia coli Methylorubrum extorquens
5.4.99.2 expression in Escherichia coli Paraburkholderia fungorum

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.4.99.2 64000
-
x * 78000, SDS-PAGE and deduced from nucleotide sequence of gene mcmA, x * 64000, SDS-PAGE and deduced from nucleotide sequence of gene mcmB Methylorubrum extorquens
5.4.99.2 78000
-
x * 78000, SDS-PAGE and deduced from nucleotide sequence of gene mcmA, x * 64000, SDS-PAGE and deduced from nucleotide sequence of gene mcmB Methylorubrum extorquens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.4.99.2 (R)-2-methylmalonyl-CoA Thermobifida fusca
-
succinyl-CoA
-
?
5.4.99.2 (R)-2-methylmalonyl-CoA Methylorubrum extorquens
-
succinyl-CoA
-
?
5.4.99.2 (R)-2-methylmalonyl-CoA Halalkalibacterium halodurans
-
succinyl-CoA
-
?
5.4.99.2 (R)-2-methylmalonyl-CoA Geobacter metallireducens
-
succinyl-CoA
-
?
5.4.99.2 (R)-2-methylmalonyl-CoA Cupriavidus metallidurans
-
succinyl-CoA
-
?
5.4.99.2 (R)-2-methylmalonyl-CoA Leptospira interrogans serovar lai str. 56601
-
succinyl-CoA
-
?
5.4.99.2 (R)-2-methylmalonyl-CoA Propionibacterium freudenreichii subsp. shermanii
-
succinyl-CoA
-
?
5.4.99.2 (R)-2-methylmalonyl-CoA Ralstonia solanacearum
-
succinyl-CoA
-
?
5.4.99.2 (R)-2-methylmalonyl-CoA Methylorubrum extorquens MCM forms a complex with MeaB succinyl-CoA
-
?
5.4.99.2 (R)-2-methylmalonyl-CoA Paraburkholderia fungorum MCM forms a complex with MeaB succinyl-CoA
-
?

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.2 Cupriavidus metallidurans
-
-
-
5.4.99.2 Geobacter metallireducens
-
-
-
5.4.99.2 Halalkalibacterium halodurans
-
-
-
5.4.99.2 Leptospira interrogans serovar lai str. 56601 Q8F222
-
-
5.4.99.2 Methylorubrum extorquens
-
-
-
5.4.99.2 Methylorubrum extorquens Q6TMA2 beta subunit
-
5.4.99.2 Methylorubrum extorquens Q84FZ1 alpha subunit
-
5.4.99.2 Paraburkholderia fungorum
-
-
-
5.4.99.2 Propionibacterium freudenreichii subsp. shermanii P11652 small subunit
-
5.4.99.2 Propionibacterium freudenreichii subsp. shermanii P11653 large subunit
-
5.4.99.2 Ralstonia solanacearum Q8Y2U5
-
-
5.4.99.2 Thermobifida fusca
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.4.99.2
-
Methylorubrum extorquens
5.4.99.2
-
Paraburkholderia fungorum

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
5.4.99.2 1.4
-
-
Methylorubrum extorquens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.99.2 (R)-2-methylmalonyl-CoA
-
Thermobifida fusca succinyl-CoA
-
?
5.4.99.2 (R)-2-methylmalonyl-CoA
-
Methylorubrum extorquens succinyl-CoA
-
?
5.4.99.2 (R)-2-methylmalonyl-CoA
-
Halalkalibacterium halodurans succinyl-CoA
-
?
5.4.99.2 (R)-2-methylmalonyl-CoA
-
Geobacter metallireducens succinyl-CoA
-
?
5.4.99.2 (R)-2-methylmalonyl-CoA
-
Cupriavidus metallidurans succinyl-CoA
-
?
5.4.99.2 (R)-2-methylmalonyl-CoA
-
Leptospira interrogans serovar lai str. 56601 succinyl-CoA
-
?
5.4.99.2 (R)-2-methylmalonyl-CoA
-
Paraburkholderia fungorum succinyl-CoA
-
?
5.4.99.2 (R)-2-methylmalonyl-CoA
-
Propionibacterium freudenreichii subsp. shermanii succinyl-CoA
-
?
5.4.99.2 (R)-2-methylmalonyl-CoA
-
Ralstonia solanacearum succinyl-CoA
-
?
5.4.99.2 (R)-2-methylmalonyl-CoA MCM forms a complex with MeaB Methylorubrum extorquens succinyl-CoA
-
?
5.4.99.2 (R)-2-methylmalonyl-CoA MCM forms a complex with MeaB Paraburkholderia fungorum succinyl-CoA
-
?

Subunits

EC Number Subunits Comment Organism
5.4.99.2 ? x * 78000, SDS-PAGE and deduced from nucleotide sequence of gene mcmA, x * 64000, SDS-PAGE and deduced from nucleotide sequence of gene mcmB Methylorubrum extorquens

Synonyms

EC Number Synonyms Comment Organism
5.4.99.2 MCM
-
Thermobifida fusca
5.4.99.2 MCM
-
Halalkalibacterium halodurans
5.4.99.2 MCM
-
Geobacter metallireducens
5.4.99.2 MCM
-
Cupriavidus metallidurans
5.4.99.2 MCM
-
Leptospira interrogans serovar lai str. 56601
5.4.99.2 MCM
-
Propionibacterium freudenreichii subsp. shermanii
5.4.99.2 MCM
-
Methylorubrum extorquens
5.4.99.2 MCM
-
Paraburkholderia fungorum
5.4.99.2 MCM
-
Ralstonia solanacearum
5.4.99.2 mcmB
-
Methylorubrum extorquens
5.4.99.2 methylmalonyl-CoA mutase
-
Thermobifida fusca
5.4.99.2 methylmalonyl-CoA mutase
-
Halalkalibacterium halodurans
5.4.99.2 methylmalonyl-CoA mutase
-
Geobacter metallireducens
5.4.99.2 methylmalonyl-CoA mutase
-
Cupriavidus metallidurans
5.4.99.2 methylmalonyl-CoA mutase
-
Leptospira interrogans serovar lai str. 56601
5.4.99.2 methylmalonyl-CoA mutase
-
Propionibacterium freudenreichii subsp. shermanii
5.4.99.2 methylmalonyl-CoA mutase
-
Methylorubrum extorquens
5.4.99.2 methylmalonyl-CoA mutase
-
Paraburkholderia fungorum
5.4.99.2 methylmalonyl-CoA mutase
-
Ralstonia solanacearum

Cofactor

EC Number Cofactor Comment Organism Structure
5.4.99.2 adenosylcobalamin
-
Thermobifida fusca
5.4.99.2 adenosylcobalamin
-
Methylorubrum extorquens
5.4.99.2 adenosylcobalamin
-
Halalkalibacterium halodurans
5.4.99.2 adenosylcobalamin
-
Geobacter metallireducens
5.4.99.2 adenosylcobalamin
-
Cupriavidus metallidurans
5.4.99.2 adenosylcobalamin
-
Leptospira interrogans serovar lai str. 56601
5.4.99.2 adenosylcobalamin
-
Propionibacterium freudenreichii subsp. shermanii
5.4.99.2 adenosylcobalamin
-
Paraburkholderia fungorum
5.4.99.2 adenosylcobalamin
-
Ralstonia solanacearum