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Literature summary extracted from

  • Monnet, C.; Nardi, M.; Hols, P.; Gulea, M.; Corrieu, G.; Monnet, V.
    Regulation of branched-chain amino acid biosynthesis by alpha-acetolactate decarboxylase in Streptococcus thermophilus (2003), Lett. Appl. Microbiol., 36, 399-405.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.1.1.5 isoleucine requirement for branched-chain amino acids, control of the pool of alpha-acetolactate by valine, leucine and isoleucine via allosteric activation, valine is more stimulatory than leucine and isoleucine Streptococcus thermophilus
4.1.1.5 leucine requirement for branched-chain amino acids, control of the pool of alpha-acetolactate by valine, leucine and isoleucine via allosteric activation, valine is more stimulatory than leucine and isoleucine Streptococcus thermophilus
4.1.1.5 valine requirement for branched-chain amino acids, control of the pool of alpha-acetolactate by valine, leucine and isoleucine via allosteric activation, valine is more stimulatory than leucine and isoleucine Streptococcus thermophilus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.5 aldC gene, expression in Escherichia coli Streptococcus thermophilus

Protein Variants

EC Number Protein Variants Comment Organism
4.1.1.5 additional information alpha-acetolactate decarboxylase-deficient mutant TIL865 Streptococcus thermophilus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.5 (S)-2-hydroxy-2-methyl-3-oxobutanoate Streptococcus thermophilus regulates leucine and valine biosynthesis by diverting the flux of alpha-acetolactate towards acetoin when branched-chain amino acids are present at a high concentration, involved in catabolism of pyruvate to acetoin, but less important function in vivo (R)-acetoin + CO2
-
 ?
4.1.1.5 (S)-2-hydroxy-2-methyl-3-oxobutanoate Streptococcus thermophilus CNRZ385 regulates leucine and valine biosynthesis by diverting the flux of alpha-acetolactate towards acetoin when branched-chain amino acids are present at a high concentration, involved in catabolism of pyruvate to acetoin, but less important function in vivo (R)-acetoin + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.5 Streptococcus thermophilus Q8L208
-
-
4.1.1.5 Streptococcus thermophilus CNRZ385 Q8L208
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.1.1.5 0.27
-
 culture in the presence of leucine and isoleucine Streptococcus thermophilus
4.1.1.5 0.472
-
 culture in the presence of leucine and valine Streptococcus thermophilus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.5 (S)-2-hydroxy-2-methyl-3-oxobutanoate
-
 Streptococcus thermophilus (R)-acetoin + CO2
-
 ?
4.1.1.5 (S)-2-hydroxy-2-methyl-3-oxobutanoate regulates leucine and valine biosynthesis by diverting the flux of alpha-acetolactate towards acetoin when branched-chain amino acids are present at a high concentration, involved in catabolism of pyruvate to acetoin, but less important function in vivo Streptococcus thermophilus (R)-acetoin + CO2
-
 ?
4.1.1.5 (S)-2-hydroxy-2-methyl-3-oxobutanoate
-
 Streptococcus thermophilus CNRZ385 (R)-acetoin + CO2
-
 ?
4.1.1.5 (S)-2-hydroxy-2-methyl-3-oxobutanoate regulates leucine and valine biosynthesis by diverting the flux of alpha-acetolactate towards acetoin when branched-chain amino acids are present at a high concentration, involved in catabolism of pyruvate to acetoin, but less important function in vivo Streptococcus thermophilus CNRZ385 (R)-acetoin + CO2
-
 ?
4.1.1.5 additional information not: alpha-acetohydroxybutyrate Streptococcus thermophilus ?
-
 ?
4.1.1.5 additional information not: alpha-acetohydroxybutyrate Streptococcus thermophilus CNRZ385 ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.5 6
-
 assay at Streptococcus thermophilus