Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Liu, J.J.; Nilsson, A.; Duan, R.D.
    In vitro effects of fat, FA, and cholesterol on sphingomyelin hydrolysis induced by rat intestinal alkaline sphingomyelinase (2002), Lipids, 37, 469-474.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.12 1-oleoyl-rac-glycerol approx. 20% stimulation at 0.4-0.8 mM, inhibition above Rattus norvegicus
3.1.4.12 1-stearoyl-rac-glycerol approx. 10% stimulation at 0.8 mM, inhibition above Rattus norvegicus
3.1.4.12 arachidonic acid approx. 20% stimulation at 0.4-0.8 mM, inhibition above Rattus norvegicus
3.1.4.12 linoleic acid approx. 20% stimulation at 0.8 mM, inhibition above Rattus norvegicus
3.1.4.12 linolenic acid approx. 30% stimulation at 0.8-1.6 mM, inhibition above Rattus norvegicus
3.1.4.12 oleic acid approx. 40% stimulation at 0.8 mM, inhibition above Rattus norvegicus
3.1.4.12 stearic acid approx. 20% stimulation at 0.4-0.8 mM, inhibition above Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.12 1,2-dioleoyl-sn-glycerol approx. 40% inhibition at 3.2 mM Rattus norvegicus
3.1.4.12 1,2-distearoyl-rac-glycerol approx. 30% inhibition at 3.2 mM Rattus norvegicus
3.1.4.12 1-oleoyl-rac-glycerol slight stimulation below 0.8 mM, approx. 50% inhibition at 3.2 mM Rattus norvegicus
3.1.4.12 1-stearoyl-rac-glycerol slight stimulation below 0.8 mM, approx. 10% inhibition at 3.2 mM Rattus norvegicus
3.1.4.12 arachidonic acid slight stimulation below 0.8 mM, approx. 50% inhibition at 3.2 mM Rattus norvegicus
3.1.4.12 ceramide strong inhibition in the presence of 0.4 mM linoleic acid Rattus norvegicus
3.1.4.12 cholesterol strong inhibition in the presence of 0.4 mM linoleic acid Rattus norvegicus
3.1.4.12 linoleic acid slight stimulation below 0.8 mM, approx. 45% inhibition at 3.2 mM Rattus norvegicus
3.1.4.12 linolenic acid stimulation below 0.8 mM, approx. 15% inhibition at 3.2 mM Rattus norvegicus
3.1.4.12 oleic acid stimulation below 0.8 mM, approx. 10% inhibition at 3.2 mM Rattus norvegicus
3.1.4.12 stearic acid slight stimulation below 0.8 mM, approx. 10% inhibition at 3.2 mM Rattus norvegicus
3.1.4.12 triolein approx. 30% inhibition at 3.2 mM Rattus norvegicus
3.1.4.12 tristearin approx. 35% inhibition at 3.2 mM Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 sphingomyelin + H2O Rattus norvegicus
-
 N-acylsphingosine + choline phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.4.12
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 intestine
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 sphingomyelin + H2O
-
 Rattus norvegicus N-acylsphingosine + choline phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 alkaline SMase
-
 Rattus norvegicus
3.1.4.12 alkaline sphingomyelinase
-
 Rattus norvegicus