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Literature summary extracted from

  • Hijarrubia, M.J.; Aparicio, J.F.; Martin, J.F.
    Nitrate regulation of alpha-aminoadipate reductase formation and lysine inhibition of its activity in Penicillium chrysogenum and Acremonium chrysogenum (2002), Appl. Microbiol. Biotechnol., 59, 270-277.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.31 Lys
-
 Acremonium chrysogenum
1.2.1.31 Lys
-
 Penicillium chrysogenum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.31 L-2-aminoadipate + NADPH + H+ Penicillium chrysogenum key enzyme in the branched pathway for lysine and beta-lactam biosynthesis of filamentous fungi. Nitrate has a strong negative effect on enzyme formation L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
 ?
1.2.1.31 L-2-aminoadipate + NADPH + H+ Acremonium chrysogenum key enzyme in the branched pathway for lysine and beta-lactam biosynthesis of filamentous fungi. Nitrate has a strong negative effect on enzyme formation L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.31 Acremonium chrysogenum
-
 wild-type strain ATCC 11550 and the improved cephalosporin producer strain C10, ATC 48272
-
1.2.1.31 Penicillium chrysogenum
-
 wild-type strain NRRL 1951 and a low-penicillin-producing strain Wis 54-1255
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.31 cell culture the activity peaks during growth-phase preceding the onset of antibiotic production, which coincides with a decrease in enzyme activity, and is lower in high cephalosporin-producing strains Acremonium chrysogenum
-
1.2.1.31 cell culture the activity peaks during growth-phase preceding the onset of antibiotic production, which coincides with a decrease in enzyme activity, and is lower in high penicillin-producing strains Penicillium chrysogenum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.31 L-2-aminoadipate + NADPH + H+
-
 Penicillium chrysogenum L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
 ?
1.2.1.31 L-2-aminoadipate + NADPH + H+
-
 Acremonium chrysogenum L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
 ?
1.2.1.31 L-2-aminoadipate + NADPH + H+ key enzyme in the branched pathway for lysine and beta-lactam biosynthesis of filamentous fungi. Nitrate has a strong negative effect on enzyme formation Penicillium chrysogenum L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
 ?
1.2.1.31 L-2-aminoadipate + NADPH + H+ key enzyme in the branched pathway for lysine and beta-lactam biosynthesis of filamentous fungi. Nitrate has a strong negative effect on enzyme formation Acremonium chrysogenum L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.31 alpha-AAR
-
 Penicillium chrysogenum
1.2.1.31 alpha-AAR
-
 Acremonium chrysogenum

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.31 NADPH no activity with NADH Penicillium chrysogenum
1.2.1.31 NADPH no activity with NADH Acremonium chrysogenum