Literature summary extracted from
Kapoor, M.; Mukhi, P.L.; Surolia, N.; Suguna, K.; Surolia, A.
Kinetic and structural analysis of the increased affinity of enoyl-ACP (acyl-carrier protein) reductase for triclosan in the presence of NAD+ (2004), Biochem. J., 381, 725-733.
Cloned(Commentary)
EC Number |
Cloned (Comment) |
Organism |
---|
1.3.1.9 |
expression in Escherichia coli |
Plasmodium falciparum |
Crystallization (Commentary)
EC Number |
Crystallization (Comment) |
Organism |
---|
1.3.1.9 |
as binary complex with NADH and as ternary complex with NAD+ and triclosan, crystals diffract to 2.5 A and 2.2 A, respectively |
Plasmodium falciparum |
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
1.3.1.9 |
triclosan |
increase in inhibition in the presence of NAD+ due to the movement of the substrate-binding loop |
Plasmodium falciparum |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
1.3.1.9 |
Plasmodium falciparum |
- |
- |
- |
Purification (Commentary)
EC Number |
Purification (Comment) |
Organism |
---|
1.3.1.9 |
recombinant PfENR |
Plasmodium falciparum |
Substrates and Products (Substrate)
EC Number |
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
---|
1.3.1.9 |
trans-but-2-enoyl-CoA + NADH |
- |
Plasmodium falciparum |
butanoyl-CoA + NAD+ |
- |
? |
|
Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
1.3.1.9 |
pfENR |
- |
Plasmodium falciparum |
Cofactor
EC Number |
Cofactor |
Comment |
Organism |
Structure |
---|
1.3.1.9 |
NADH |
- |
Plasmodium falciparum |
|