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Literature summary extracted from

  • Lemire, B.D.; Oyedotun, K.S.
    The Saccharomyces cerevisiae mitochondrial succinate:ubiquinone oxidoreductase (2002), Biochim. Biophys. Acta, 1553, 102-116.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.3.5.1 D117V reduced covalent FAD content Saccharomyces cerevisiae
1.3.5.1 H99L reduced covalent FAD content Saccharomyces cerevisiae
1.3.5.1 K132E mutation in Sdh4 subunit affects heme assembly Saccharomyces cerevisiae
1.3.5.1 K132G mutation in Sdh4 subunit affects heme assembly Saccharomyces cerevisiae
1.3.5.1 K132Q mutation in Sdh4 subunit, reduced heme content Saccharomyces cerevisiae
1.3.5.1 K132V mutation in Sdh4 subunit affects heme assembly Saccharomyces cerevisiae

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.5.1 2-n-heptyl-4-hydroxyquinoline-N-oxide
-
 Saccharomyces cerevisiae
1.3.5.1 2-Thenoyltrifluoroacetone
-
 Saccharomyces cerevisiae
1.3.5.1 3-methylcarboxin
-
 Saccharomyces cerevisiae
1.3.5.1 sec-butyl-4,6-dinitrophenol non-competitive inhibition Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.5.1 membrane SDH is attached to the membrane through Sdh3 and Sdh4 subunits Saccharomyces cerevisiae 16020
-
1.3.5.1 mitochondrion
-
 Saccharomyces cerevisiae 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.3.5.1 Iron Sdh2 subunit contains [2Fe-2S], 4[Fe-4S] and [3Fe-4S] clusters Saccharomyces cerevisiae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.3.5.1 16638
-
 1 * 70185, + 1 * 30229, + 1 * 16675, + 1 * 16638, subunits Sdh1, Sdh2, Sdh3 and Sdh4 Saccharomyces cerevisiae
1.3.5.1 16675
-
 1 * 70185, + 1 * 30229, + 1 * 16675, + 1 * 16638, subunits Sdh1, Sdh2, Sdh3 and Sdh4 Saccharomyces cerevisiae
1.3.5.1 30229
-
 1 * 70185, + 1 * 30229, + 1 * 16675, + 1 * 16638, subunits Sdh1, Sdh2, Sdh3 and Sdh4 Saccharomyces cerevisiae
1.3.5.1 70185
-
 1 * 70185, + 1 * 30229, + 1 * 16675, + 1 * 16638, subunits Sdh1, Sdh2, Sdh3 and Sdh4 Saccharomyces cerevisiae
1.3.5.1 150000
-
 blue native gel electrophoresis Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.5.1 succinate + ubiquinone Saccharomyces cerevisiae
-
 fumarate + ubiquinol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.5.1 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.5.1 succinate + ubiquinone
-
 Saccharomyces cerevisiae fumarate + ubiquinol
-
 ?

Subunits

EC Number Subunits Comment Organism
1.3.5.1 tetramer 1 * 70185, + 1 * 30229, + 1 * 16675, + 1 * 16638, subunits Sdh1, Sdh2, Sdh3 and Sdh4 Saccharomyces cerevisiae

Synonyms

EC Number Synonyms Comment Organism
1.3.5.1 SDH
-
 Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.5.1 FAD localized in Sdh1, i.e. the flavoprotein subunit Saccharomyces cerevisiae