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Literature summary extracted from

  • Nguyen, E.; Picklo, M.J., Sr.
    Inhibition of succinic semialdehyde dehydrogenase activity by alkenal products of lipid peroxidation (2003), Biochim. Biophys. Acta, 1637, 107-112.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.24 4-hydroxy-trans-2-nonenal IC50: 0.11 mM Rattus norvegicus
1.2.1.24 acrolein irreversible, noncompetitive, IC50: 0.015 mM Rattus norvegicus
1.2.1.24 additional information no inhibition by 0.1 mM trans-2-hexenal and 0.1 mM crotonaldehyde Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.24 0.0039
-
 succinate semialdehyde
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.24 mitochondrion
-
 Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.24 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.24 brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.24 succinate semialdehyde + NAD+ + H2O
-
 Rattus norvegicus succinate + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.24 SSADH/ALDH5A1
-
 Rattus norvegicus
1.2.1.24 succinic semialdehyde dehydrogenase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.24 NAD+
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.2.1.24 0.015
-
 irreversible, noncompetitive, IC50: 0.015 mM Rattus norvegicus acrolein
1.2.1.24 0.11
-
 IC50: 0.11 mM Rattus norvegicus 4-hydroxy-trans-2-nonenal