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Literature summary extracted from

  • Oubrie, A.
    Structure and mechanism of soluble glucose dehydrogenase and other PQQ-dependent enzymes (2003), Biochim. Biophys. Acta, 1647, 143-151.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.1.5.2 crystal structure analysis of enzyme in ternary complex with beta-D-glucose and PQQ Acinetobacter calcoaceticus
1.1.99.35 structure of soluble isoform sGDH with the cofactor at 2.2 A resolution, and of its complex with reduced cofactor and D-glucose at 1.9 A resolution. Evidence for a mechanism comprisding general base-catalyzed hydride transfer Acinetobacter calcoaceticus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.5.2 cytoplasm soluble enzyme sGDH Acinetobacter calcoaceticus 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.5.2 beta-D-glucose + ubiquinone Acinetobacter calcoaceticus
-
 D-glucono-1,5-lactone + ubiquinol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.5.2 Acinetobacter calcoaceticus
-
 soluble enzyme form sGDH
-
1.1.99.35 Acinetobacter calcoaceticus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.5.2 D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol active site structure from crystal structure, and detailed catalytic mechanism Acinetobacter calcoaceticus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.5.2 beta-D-glucose + ubiquinone
-
 Acinetobacter calcoaceticus D-glucono-1,5-lactone + ubiquinol
-
 ?
1.1.5.2 beta-D-glucose + ubiquinone redox-related structural changes, overview Acinetobacter calcoaceticus D-glucono-1,5-lactone + ubiquinol
-
 ?
1.1.99.35 additional information mechanism comprises general base-catalyzed hydride transfer Acinetobacter calcoaceticus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.5.2 More redox-related structural changes, overview Acinetobacter calcoaceticus

Synonyms

EC Number Synonyms Comment Organism
1.1.5.2 sGDH
-
 Acinetobacter calcoaceticus
1.1.5.2 soluble glucose dehydrogenase
-
 Acinetobacter calcoaceticus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.5.2 pyrroloquinoline quinone i.e. PQQ, dependent on, functions as a redox mediator by transfer of hydride ions and electrons, redox-related structural changes, overview Acinetobacter calcoaceticus